43014-31-9Relevant academic research and scientific papers
BENZOSUBERENE ANALOGUES AND RELATED COMPOUNDS WITH ACTIVITY AS ANTICANCER AGENTS
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, (2020/03/01)
A series of benzosuberene analogues demonstrate effective inhibition of tubulin polymerization, cytotoxicity against human cancer cell lines, and vascular disruption in tumors.
Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization
Niu, Haichan,Strecker, Tracy E.,Gerberich, Jeni L.,Campbell, James W.,Saha, Debabrata,Mondal, Deboprosad,Hamel, Ernest,Chaplin, David J.,Mason, Ralph P.,Trawick, Mary Lynn,Pinney, Kevin G.
, p. 5594 - 5615 (2019/06/07)
A promising design paradigm for small-molecule inhibitors of tubulin polymerization that bind to the colchicine site draws structural inspiration from the natural products colchicine and combretastatin A-4 (CA4). Our previous studies with benzocycloalkeny
Synthesis and pharmacological evaluation of 5,6,7,8-tetrahydro-6-amino>-1,2-naphthalenediol: a novel non-selective dopamine-receptor agonist
Copinga, Swier,Dijkstra, Durk,Vries, Jan B. de,Grol, Cor J.,Horn, Alan S.
, p. 137 - 142 (2007/10/02)
Based on the hypothesis that simultaneous stimulation of dopamine-D1 and -D2 receptors could be beneficial for the treatment of Parkinson's disease, we prepared 5,6,7,8-tetrahydro-6-amino>-1,2-naphthalenedi
