43024-15-3

Basic information

• Product Name: 3-Amino-4-ethylpyrazole
• Synonyms: 3-Amino-4-ethylpyrazole;4-ethyl-1H-pyrazol-3-amine;3-Amino-4-ethyl-1H-pyrazole;4-ethyl-1(2)H-pyrazol-3-ylaMine
• CAS NO: 43024-15-3
• Molecular Formula: C₅H₉N₃
• Molecular Weight: 111.15
• Mol File: 43024-15-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 307.224 °C at 760 mmHg
• Flash Point: 165.119 °C
• Appearance: /Solid
• Density: 1.157 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: 2-8°C(protect from light)
• PKA: 16.12±0.50(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-Amino-4-ethylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-ethylpyrazole(43024-15-3)
• EPA Substance Registry System: 3-Amino-4-ethylpyrazole(43024-15-3)

Safety Data

• Hazardous Substances Data: 43024-15-3(Hazardous Substances Data)

Usage

Uses

3-Amino-4-ethyl-1H-pyrazole is employed as a intermediate for chemical research and pharmaceutical.

InChI:InChI=1/C5H9N3/c1-2-4-3-7-8-5(4)6/h3H,2H2,1H3,(H3,6,7,8)

Upstream product

• 43024-14-2 α-formyl-n-butyronitrile 
• 109-74-0 propyl cyanide 
• 109-94-4 formic acid ethyl ester 
• 1010800-27-7 3-amino-4-ethylpyrazole oxalate 
• 107-31-3 Methyl formate 

Downstream Products

• 2020052-55-3 (S)-N-(3-(3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-ylamino)phenyl)acrylamide 

Relevant articles and documents

CDK inhibitor based on organic arsine as well as preparation method and application of CDK inhibitor

The invention provides a CDK inhibitor based on organic arsine as well as a preparation method and application of the CDK inhibitor. Specifically, the invention providese compounds of Formula I, or stereoisomers or tautomers thereof, or pharmaceutically acceptable salts, hydrates or solvates thereof; and the invention also discloses a preparation method and application thereof. Definitions of allgroups in the formula are shown in the specification.

PYRAZOLO[1,5-A][1,3,5]TRIAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS CDK INHIBITORS

The present invention provides substituted pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives of formula (I), which are therapeutically useful, particularly as selective transcriptional CDK inhibitors including CDK7, CDK9, CDK12, CDK13 and CDK18, more particularly transcriptional CDK7 inhibitors wherein X, ring A, ring B, L1, L2, R1,R2, R3, R4, R6, m, n and p have the meanings given in the specification and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder associated with selective transcriptional CDKs in a mammal. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof.

Synthesis of 3-amino-4-substituted pyrazole derivatives

This application discloses a novel process to synthesize 3-amino-4-substituted pyrazole derivatives, which may be used, for example, as intermediates to prepare compounds having, for example, pharmaceutical utility.