43043-28-3Relevant academic research and scientific papers
Studies of Collectors. Part 12. The Flotation of Gallium Ion with Polyphenol-type Surfactants
Koide, Yoshifumi,Sakurai, Katsuhiro,Shosenji, Hideto,Yamada, Kimiho
, p. 641 - 645 (1990)
Polyphenol-type surfactants bearing 1,2-benzenediol or 1,2,3-trihydroxybenzene units were prepared and applied as flotation collectors for Ga(3+).The surfactants exhibited a lowering of surface tension at pH 11 (32-47 dyn cm-1.Gallium(III) was highly floated (80-90percent) at pH 3-8 with equimolar Cn-1H2n-1C(O)C6H3(OH)2 (n=8 or 12) or C7H15C(O)C6H2(OH)3, but not as highly (60percent) with C12H25S4.8(CH2CHCO2H)9.5H.The floatabilities of Ga(3+) in 1 mol dm-3 NaOH were 86-99percent, those in 3 mol dm-3 NaOH were 63-67percent, and those in 5 mol dm-3 NaOH were 26-39percent by using a six-fold molar excess of Cn-1H2n-1C(O)C6H3(OH)2 (n=12 or 18).On the other hand, the floatabilities from 1-5 mol dm-3 NaOH solutions when Cn-1H2n-1C(O)C6H2(OH)3 was added were nearly constant (58-59percent with n=12 and 31-35percent with n=18).The Ga(3+) in a Ga(3+)-Al(3+) mixture was floated selectively at pH3-5 by using C7H15C(O)C6H3(OH)2 or C7H15C(O)C6H2(OH)3.Moreover, the polyphenol-type surfactants in these flotation systems were almost entirely absent (-5 mol dm-3) from 3-5 mol dm-3 NaOH solutions and little decomposed.
Synthesis, antiproliferative, and c-Src kinase inhibitory activities of 4-oxo-4H-1-benzopyran derivatives
Chand, Karam,Tiwari, Rakesh K.,Kumar, Sumit,Shirazi, Amir Nasrolahi,Sharma, Sweta,Van Der Eycken, Erik V.,Parmar, Virinder S.,Parang, Keykavous,Sharma, Sunil K.
, p. 562 - 572 (2015/03/30)
A new class of 4-oxo-4H-1-benzopyran derivatives were synthesized and their antiproliferative activity examined against a panel of three human cancer cell lines, that is, breast carcinoma (MDA-MB-468), ovarian adenocarcinoma (SK-OV-3), and colorectal adenocarcinoma (HT-29). Two compounds, that is, 3-hexyl-7,8-dihydroxy-4-oxo-4H-1-benzopyran and (E)-ethyl 3-(7-methoxy-4-oxo-4H-1-benzopyran-3-yl)acrylate were found to be potent against all three cancer cell lines studied at 50 μM concentration. Also, the inhibitory potency of the compounds was evaluated against active Src kinase. A few of these compounds exhibited modest Src kinase inhibitory activity (IC50 = 52-57 μM). Structure-activity relationship studies with respect to the nature and position of substituents on the lead compounds could be further exploited for the design and development of more potent antiproliferative agents and/or Src kinase inhibitors.
The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors
Xiao, Zhu-Ping,Ma, Tao-Wu,Fu, Wei-Chang,Peng, Xiao-Chun,Zhang, Ai-Hua,Zhu, Hai-Liang
experimental part, p. 5064 - 5070 (2010/12/24)
Some pyrogallol and catechol derivatives were synthesized, and their urease inhibitory activity was evaluated by using acetohydroxamic acid (AHA), a well known Helicobacter pylori urease inhibitor, as positive control. The assay results indicate that many compounds have showed potential inhibitory activity against H. pylori urease. 4-(4-Hydroxyphenethyl)phen-1,2-diol (2a) was found to be the most potent urease inhibitor with IC50s of 1.5 ± 0.2 μM for extracted fraction and 4.2 ± 0.3 μM for intact cell, at least 10 times and 20 times lower than those of AHA (IC50 of 17.2 ± 0.9 μM, 100.6 ± 13 μM), respectively. This finding indicate that 2a would be a potential urease inhibitor deserves further research. Molecular dockings of 2a into H. pylori urease active site were performed for understanding the good activity observed.
