430473-70-4

Upstream product

• 430473-69-1 ((E)-(2R,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enyloxy)-triisopropyl-silane 
• 100-39-0 benzyl bromide 
• 113350-84-8 (2R,3R)-(-)-2,3-bis(phenylmethoxy)-1,4-butanediol 
• 171964-40-2 diisopropyl (2S,3S)-2,3-dibenzyloxysuccinate 
• 1026450-96-3 (2S,3R)-2,3-Bis-benzyloxy-4-triisopropylsilanyloxy-butyraldehyde 
• 430473-68-0 (2R,3R)-2,3-Bis-benzyloxy-4-triisopropylsilanyloxy-butan-1-ol 

Downstream Products

• 430473-73-7 (E)-(2R,3R,4R,5R)-4,5-Bis-benzyloxy-3-hydroxy-2-methoxy-8-methyl-non-6-enoic acid ((S)-2-oxo-azepan-3-yl)-amide 
• 430473-72-6 (E)-(2R,3R,4R,5R)-4,5-Bis-benzyloxy-3-hydroxy-2-methoxy-8-methyl-non-6-enethioic acid S-phenyl ester 
• 430473-71-5 (E)-(2S,3R)-2,3-Bis-benzyloxy-6-methyl-hept-4-enal 

Relevant academic research and scientific papers

Total synthesis of bengamide E

A total synthesis of bengamide E is reported. The synthesis includes the utilization of D-tartrate as the chiral building block, construction of the E-olefin by the Julia protocol, an anti-aldol reaction to generate C-2 and C-3 stereocenters, and coupling of the thioester with caprolactam hydrochloride using sodium 2-ethylhexanoate.