609771-66-6

Upstream product

• 24599-58-4 2,5-dimethoxy toluene 
• 13321-74-9 1-bromo-2,5-dimethoxy-4-methylbenzene 
• 16088-62-3 (S)-Propylene oxide 

Downstream Products

• 609771-67-7 (2S)-1-(2,5-dimethoxy-4-methylphenyl)-2-propyl tosylate 
• 609771-68-8 (2S)-1-(2,5-dimethoxy-4-methylphenyl)-2-propyl azide 
• 43061-13-8 (-)-DOM 
• 43061-14-9 (+)-DOM 

Relevant academic research and scientific papers

Stereospecific synthesis of amphetamines

Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.