43119-29-5

Upstream product

• 26054-46-6 (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one 
• 634189-19-8 (E)-7-Oxo-hept-2-enoic acid (3R,3aR,6S,6aR)-6-benzyloxy-hexahydro-furo[3,2-b]furan-3-yl ester 

Downstream Products

• 475995-01-8 (1S,2S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]cyclopentanol 
• 475995-15-4 (S)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]cyclopentanone 
• 642454-47-5 (1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentyl benzoate 
• 642454-45-3 (1S,2S)-2-[2-(tert-butyldiphenylsilyloxy)-1-hydroxyethyl]cyclopentyl benzoate 
• 642454-39-5 (1S,2S)-2-(2-trityloxyethyl)cyclopentyl benzoate 
• 642454-61-3 (1S,2R)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanol 
• 642454-63-5 (2S)-2-[2-(tert-butyldiphenylsilyloxy)-1-(methoxymethoxy)ethyl]cyclopentanone 
• 642454-37-3 (1S,2S)-2-(2-trityloxyethyl)cyclopentanol 
• 642454-43-1 (1S,2S)-2-(1,2-dihydroxyethyl)cyclopentyl benzoate 
• 642454-41-9 (1S,2S)-2-(2-hydroxyethyl)cyclopentyl benzoate 
• 642454-68-0 Benzoic acid (1S,2S)-2-(2-oxo-ethyl)-cyclopentyl ester 

Relevant academic research and scientific papers

Common Modes of Action of γ-Butyrolactones and Pentylenetetrazol on the GABAA Receptor-Ionophore Complex

The effects of pentylenetetrazol and bicyclic γ-butyrolactones of similar stereostructures were studied on the convulsant and benzodiazepine binding sites and chloride ionophore activity of the γ-aminobutyric acid (GABAA) receptor-complex. Bicyclic γ-butyrolactones displayed millimolar IC50 values and low stereoselectivities on [35S]t-butylbicyclophosphorothionate (TBPS) binding to the convulsant sites in synaptosomal membranes of rat forebrains. Ring saturation of bicyclic γ-butyrolactones decreased their IC50 values by one order of magnitude. The IC50 values of saturated bicyclic γ-butyrolactones and pentylenetetrazol were increased by GABA versus its antagonist R 5135 (3α-hydroxy-16-imino-5β,17-aza-androstan-11-one). A bicyclic γ-butyrolactone and pentylenetetrazol accelarated the dissociation of [35S]TBPS, displaced [3H]flumezenil binding in two phases and blocked the muscimol-elicited chloride currents in patch-clamped cortical neurones in culture in a similar manner. These similar effects on binding and ionophore function suppert their common modes of action on the GABAA receptor-ionophore complex.

Aldehyde-alkene cyclizations via O-stannyl ketyl radicals using sugars as chiral auxiliaries

This investigation illustrates the utility of two inexpensive carbohydrate derivatives as sources of asymmetry for aldehyde-alkene radical cyclizations. Diastereomeric ratios as high as 9:1 were achieved with an ester-appended (+)-isosorbide and 100:1 for