43121-58-0Relevant academic research and scientific papers
Enaminones as building blocks in heterocyclic synthesis: New syntheses of nicotinic acid and thienopyridine derivatives
Abdelkhalik, Mervat Mohammed,Eltoukhy, Afaf Mohammed,Agamy, Samia Michel,Elnagdi, Mohammed Hilmy
, p. 431 - 434 (2007/10/03)
Reacting 1,3-diphenyl-propan-2-one with equimolecular amount of dimethylformamide dimethylacetal afforded the enaminone 4. This when reacted with another equimolecular amount of dimethylformamide dimethylacetal afforded the dienaminone 5. Compound 4 condenses with cyanothioacetamide and with cyanoacetamide to yield 2-thioxo- and 2-oxo-pyridine-3-carbonitrile derivatives 6a,b respectively. Compound 6a reacted with (x-chloroacetone 8 to yield the thieno[2,3-b]pyridine derivative 10 that cyclized further into 4,7,8-trisubstituted pyrido[2′,3′:2,3] thieno[4,5-d]pyrimidine 12. Compound 4 also afforded 2,5,6-trisubstituted nicotinic acid ethyl ester 13 by reaction with ethyl acetoacetate in acetic acid in the presence of ammonium acetate. The dienaminone 5 reacted with acetic acid, ammonium acetate/acetic acid, phenylhydrazine and 5-amino-3-methylpyrazole yielding 3,5-diphenyl-pyran- 4-one 15a, 3,5-diphenyl-1H-pyridin-4-one 15b and 1,3,5-trisubstituted pyridin-4-ones 16a-b.
3-Phenyl-5-substituted-4(1H)-pyridones(thiones)
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, (2008/06/13)
A class of 3-phenyl-4(1H)-pyridones and pyridinethiones are broad-spectrum herbicides. The new compounds are characterized by a small substituent on the nitrogen, and usually bear a 5-substituent chosen from a class described herein. The phenyl ring may be substituted. The compounds are effective herbicides when applied both before and after the emergence of weeds, and are particularly useful for the control of weeds in cotton and rice cropland.
