4774-33-8Relevant academic research and scientific papers
Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides
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, (2008/06/13)
This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.
Synthesis and Nitration of N,N′-Diacyl-2-nitro-1,1-alkanediamines
Terpigorev,Germanova,Bazanov
, p. 1712 - 1720 (2007/10/03)
Reactions of primary and secondary nitroalkanes with N,N′-bis(ethoxycarbonyl)formamidine and N,N′-diacylformamidines generated in situ from the corresponding acylamine, triethyl orthoformate, and 1,1-dinitroethane result in formation of N,N′-diacyl-2-nitro-1,1-alkanediamines. Methyl-N-nitroamine and 2-fluoro-2,2-dinitroethanol react with N,N′-bis(ethoxycarbonyl)formamidine to give N2-ethoxycarbonyl-N1-methyl-N1-nitroformamidine and 2-fluoro-2,2-dinitroethyl N-ethoxycarbonylformimidate, respectively. Nitration of N,N′-diacyl-2-nitro-1,1-alkanediamines, depending on the conditions and the number of nitro groups, leads to N,N′-dinitro- or N-mononitro derivatives or is accompanied by decomposition into polynitro-alkanes and ethyl N-nitrocarbamate.
