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CAS

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43139-18-0

4-Isopropoxypiperidine is an organic compound with the chemical structure featuring a piperidine ring substituted with an isopropoxy group at the 4-position. It is a versatile intermediate in the synthesis of various pharmaceutical compounds and has potential applications in the development of novel therapeutic agents.

43139-18-0

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43139-18-0 Usage

Uses

Used in Pharmaceutical Industry:
4-Isopropoxypiperidine is used as a reagent for the preparation of quinoline and isoquinoline derivatives, which are P2X7 antagonists. These antagonists are useful in the treatment of P2X7 receptor-associated diseases, such as chronic pain, inflammation, and neurodegenerative disorders. 4-ISOPROPOXY-PIPERIDINE's unique structure allows for the development of targeted therapies with potential benefits in managing these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 43139-18-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,1,3 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 43139-18:
(7*4)+(6*3)+(5*1)+(4*3)+(3*9)+(2*1)+(1*8)=100
100 % 10 = 0
So 43139-18-0 is a valid CAS Registry Number.

43139-18-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Isopropoxypiperidine

1.2 Other means of identification

Product number -
Other names 4-propan-2-yloxypiperidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:43139-18-0 SDS

43139-18-0Downstream Products

43139-18-0Relevant articles and documents

A biocatalytic/reductive etherification approach to substituted piperidinyl ethers

Kuethe, Jeffrey T.,Janey, Jacob M.,Truppo, Matthew,Arredondo, Juan,Li, Tao,Yong, Kelvin,He, Shuwen

, p. 4563 - 4570 (2014/06/10)

A synthetically useful protocol has been developed for the preparation of highly functionalized piperidinyl ethers. Biocatalytic reduction of cyclhexanones 7, 10, and 14 allows for the preparation of both cis- and trans diastereomers with an extremely high degree of stereochemical control. Reductive etherification of the corresponding trimethylsilylethers with 1-(benzyloxycarbonyl)-4-piperidinone 17 in the presence of triethylsilane and catalytic TMSO-Tf provides the desired piperidinyl ethers in good to excellent yields. Finally hygrogenolysis of the nitrogen protecting group leads to piperidinyl ethers in near quantitative yields. Application of the methodology to a range of piperidinyl ethers, including the core scaffolds of diphenylpyraline and ebastine, is also described.

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