4315-66-6

Usage

Type of compound

Chemical compound

Derivative of

Barbituric acid

Usage

Synthesis of other organic compounds

Pharmacological properties

Potential as an antiepileptic and sedative drug

Class

Barbiturate class of drugs

Mechanism of action

Central nervous system depressants

Decline in use

Due to potential for abuse and addiction, and availability of safer and more effective alternatives

Upstream product

• 4315-71-3 2-phenyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxylic acid 
• 122707-25-9 6-amino-1,3-dimethyl-5-phenylazouracilate 
• 65172-73-8 5,7-dimethyl-2-phenyl-2H,5H-pyrimido[4,5-e][1,2,4]triazine-3,6,8-trione 

Downstream Products

• 38560-92-8 4-[4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-benzenesulfonyl]-morpholine 
• 74875-33-5 2-[4-(Piperidine-1-sulfonyl)-phenyl]-2H-[1,2,4]triazine-3,5-dione 
• 74875-31-3 4-(3,5-Dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-(1,1,3,3-tetramethyl-butyl)-benzenesulfonamide 
• 74875-32-4 C₁₅H₁₃N₅O₆S₂ 
• 164155-56-0 2-(3,5-Dichlorophenyl)-2,3,4,5-tetrahydro-1,2,4-triazin-3-one-5-thione 
• 74875-30-2 4-(3,5-Dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-benzenesulfonyl chloride 
• 76789-41-8 1-phenyl-3-methyl-6-azauracil 

Relevant academic research and scientific papers

Anticoccidial derivatives of 6-azauracil. II. High potency and long plasma life of N1-phenyl structures

Attachment of substituted phenyl side chains at N1 of 6-azauracil caused striking increases in plasma life and anticoccidial potency. The increases were related in part to the acidity of the imide hydrogen. Maximum effects were shown by phenyl rings substituted in both meta positions by compact, electron-withdrawing, lipophilic substituents, as in 1-(3',5'-dichlorophenyl)-6 azauracil, which had a plasma half-life of 160 h and a potency 250-fold greater than that of 6-azauracil.