4315-68-8Relevant academic research and scientific papers
A mild and efficient copper-mediated N-arylation of 6-azauracil with corresponding boronic acids and their antibacterial activity
Gulipalli, Kali Charan,Bodige, Srinu,Ravula, Parameshwar,Bolla, R. Sekhar,Endoori, Srinivas,Cherukumalli, Purna Koteswara Rao,Seelam, Nareshvarma
, p. 2495 - 2501 (2018/10/05)
A convenient synthetic strategy is reported for the synthesis of N-arylated 6-azauracil through Chan-Lam cross-coupling. A variety of N-arylated 6-azauracil derivatives were synthesized in moderate to good yields by cross-coupling of 6-azauracil with arylboronic acids in the presence of Cu(OAc)2 and pyridine. However the arylation position is confirmed in the case of 2-(3,5-dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione (3a), by preparing the compound in a traditional method and compared the chemical shift of the NH proton at N-3 position. Further, the synthesized compounds were screened for their antibacterial activity using agar well diffusion method. The results revealed that most of the synthesized moieties possessing promising therapeutic nature.
Anticoccidial derivatives of 6-azauracil. II. High potency and long plasma life of N1-phenyl structures
Miller,Mylari,Howes Jr.,Lynch,Lynch,Koch
, p. 1483 - 1487 (2007/10/08)
Attachment of substituted phenyl side chains at N1 of 6-azauracil caused striking increases in plasma life and anticoccidial potency. The increases were related in part to the acidity of the imide hydrogen. Maximum effects were shown by phenyl rings substituted in both meta positions by compact, electron-withdrawing, lipophilic substituents, as in 1-(3',5'-dichlorophenyl)-6 azauracil, which had a plasma half-life of 160 h and a potency 250-fold greater than that of 6-azauracil.
