43183-12-6Relevant academic research and scientific papers
Synthesis of s-pixyl derivatives for mass spectrometric applications
Khan, Safraz,Bernad, Pablo L.,Korshun, Vladimir A.,Southern, Edwin M.,Shchepinov, Mikhail S.
, p. 2453 - 2456 (2007/10/03)
Synthesis of novel S-pixyls based on the thioxanthyl skeleton is described. Thioxanthone derivatives were prepared by a regioselective intramolecular Friedel-Crafts acylation reaction and converted into S-pixyl derivatives by Grignard synthesis. S-Pixyl carbocations stabilised by electron donating groups on the thioxanthyl backbone produced exceptional mass spectra under (MA)LDI conditions (laser desorption ionisation, both with and without matrix), and can be detected down to femtomol levels. Georg Thieme Verlag Stuttgart.
New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: Chemistry and pharmacological evaluation
Liao, Yi,Venhuis, Bastiaan J.,Rodenhuis, Nienke,Timmerman, Wia,Wikstr?m, H?kan,Meier, Eddie,Bartoszyk, Gerd D.,B?ttcher, Henning,Seyfried, Christoph A.,Sundell, Staffan
, p. 2235 - 2244 (2007/10/03)
A series of 2- or 8-trifluoromethylsulfonyloxy (TfO) and 2- or 8- methylsulfonyloxy (MsO) 11-piperazinyldibenzodiazepines, -oxazepines, and - thiazepines were synthesized and evaluated in pharmacological models for their potential clozapine-like propertie
POTENTIAL ANTIDEPRESSANTS: 2-(METHOXY- AND HYDROXY-PHENYLTHIO)BENZYLAMINES AS SELECTIVE INHIBITORS OF 5-HYDROXYTRYPTAMINE RE-UPTAKE IN THE BRAIN
Jilek, Jiri,Sindelar, Karel,Pomykacek, Josef,Kmonicek, Vojtech,Sedivy, Zdenek,et al.
, p. 3294 - 3338 (2007/10/02)
2-, 3- and 4-Methoxythiophenol, and 2,4-, 2,5- and 3,4-dimethoxythiophenol were transformed in two steps to the corresponding 2-(methoxyphenylthio)benzoyl chlorides XIII which were reacted with ammonia, methylamine, dimethylamine, diethylamine, dipropylamine, and di(2-propyl)amine to give the amides XIV-XIX.These were reduced mostly with lithium aluminium hydride to the amines II-VII.These methoxylated amines were demethylated mostly either by heating with pyridine hydrochloride or by treatment with boron tribromide.Some of the 2-(methoxy- and hydroxy-phenylthio)benzylamines prepared, especially compounds II, III, XXI, and XXII, indicated properties of potential antidepressants being highly active and selective inhibitors of 5-hydroxytryptamine re-uptake in the brain structures and having the typical antireserpine activity.The most interesting compound of the series is XXIb (hydrogen maleate VUFB-15 468) which is undergoing preclinical studies.On the basis of its structure, some further compounds (XXVII-XXIX, XXXIX-XLI) were prepared by various methods.
PHOTOCHEMISTRY OF HYDROXAMIC ACIDS
Hosangadi, B.D.,Chhaya, P.N.,Nimbalkar, M.M.,Patel, N.R.
, p. 5375 - 5380 (2007/10/02)
Photochemical reactions of hydroxamic acids have been studied.The intermediacy of a RCONH(.) radical is postulated, based on oxidations achieved with DCA under photochemical conditions.
