43187-68-4

Usage

Uses

Used in Organic Synthesis:
1-(3-(trifluoromethyl)phenyl)cyclopropan-1-ol is utilized as a building block and intermediate in the production of various compounds. Its unique properties make it a versatile component in the creation of a wide array of chemical products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(3-(trifluoromethyl)phenyl)cyclopropan-1-ol is employed for its potential in the development of new drugs. Its distinctive chemical structure allows for the exploration of novel therapeutic agents.
Used in Agrochemicals:
1-(3-(trifluoromethyl)phenyl)cyclopropan-1-ol also holds promise in the field of agrochemicals, where it may contribute to the development of innovative products for agricultural applications.
Used in Specialty Chemicals:
1-(3-(trifluoromethyl)phenyl)cyclopropan-1-ol's unique attributes extend its utility to the domain of specialty chemicals, where it can be harnessed to create specialized products with tailored properties for specific applications.

Upstream product

• 64362-16-9 trimethyl({1-[3-(trifluoromethyl)phenyl]ethenyl}oxy)silane 
• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 1006613-82-6 1-(benzenesulfonyl)cyclopropanol 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 76783-59-0 ethyl 3-(trifluoromethyl)benzoate 
• 925-90-6 ethylmagnesium bromide 

Relevant academic research and scientific papers

Iron- or silver-catalyzed oxidative fluorination of cyclopropanols for the synthesis of β-fluoroketones

The FeIII- or AgI-catalyzed oxidative fluorination of cyclopropanols via radical rearrangement is disclosed. This process features a straightforward and highly effective protocol for the site-specific synthesis of β-fluoroketones and represents an expedient method for the synthesis of γ-, δ- and ε-fluoroketones. Notably, this reaction proceeds at room temperature and tolerates a diverse array of cyclopropanols.

Catalytic Asymmetric Allylic Substitution with Copper(I) Homoenolates Generated from Cyclopropanols

By using copper(I) homoenolates as nucleophiles, which are generated through the ring-opening of 1-substituted cyclopropane-1-ols, a catalytic asymmetric allylic substitution with allyl phosphates is achieved in high to excellent yields with high enantioselectivity. Both 1-substituted cyclopropane-1-ols and allylic phosphates enjoy broad substrate scopes. Remarkably, various functional groups, such as ether, ester, tosylate, imide, alcohol, nitro, and carbamate are well tolerated. Moreover, the present method is nicely extended to the asymmetric construction of quaternary carbon centers. Some control experiments argue against a radical-based reaction mechanism and a catalytic cycle based on a two-electron process is proposed. Finally, the synthetic utilities of the product are showcased by means of the transformations of the terminal olefin group and the ketone group.

General Synthesis of Cyclopropanols via Organometallic Addition to 1-Sulfonylcyclopropanols as Cyclopropanone Precursors

The addition of organometallic reagents to ketones constitutes one of the most straightforward synthetic approaches to tertiary alcohols. However, due to the absence of a well-behaved class of cyclopropanone surrogates accessible in enantioenriched form, such a trivial synthetic disconnection has received very little attention in the literature for the formation of tertiary cyclopropanols. In this work, we report a simple and high-yielding synthesis of 1-substituted cyclopropanols via the addition of diverse organometallic reagents to 1-phenylsulfonylcyclopropanols, acting here as in situ precursors of the corresponding cyclopropanones. The transformation is shown to be amenable to sp-, sp2-, or sp3-hybridized organometallic C-nucleophiles under mild conditions, and the use of enantioenriched substrates led to highly diastereoselective additions and the formation of optically active cyclopropanols.