431879-25-3

Upstream product

• 431879-36-6 3-[4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-phenyl]-propionic acid methyl ester 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 1135-23-5 3-(4-hydroxy-3-methoxyphenyl)propionic acid 
• 56024-44-3 methyl 3-(4-hydroxy-3-methoxyphenyl)propanoate 

Downstream Products

• 124988-58-5 (S)-4-<<4-(benzyloxy)-3-methoxyphenyl>methyl>dihydro-2(3H)-furanone 
• 111266-02-5 (S)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone 
• 431879-27-5 (4S)-(-)-4-{[4-(tert-butyldiphenylsilanyloxy)-3-methoxyphenyl]methyl}tetrahydrofuran-2-one 
• 431879-26-4 3-[4-(tert-butyldiphenylsilanoxy)-3-methoxyphenyl]propyl diazoacetate 
• 431879-31-1 3-(4-benzyloxy-3-methoxy-benzyl)-1-(4-benzyloxy-3-methoxy-phenyl)-4-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol 

Relevant academic research and scientific papers

Total synthesis of (S)-(+)-imperanene. Effective use of regio- and enantioselective intramolecular carbon-hydrogen insertion reactions catalyzed by chiral dirhodium(II) carboxamidates

The total synthesis of (S)-(+)-imperanene, a natural product found in Chinese medicine, has been completed in 12 steps from a commercially available cinnamic acid. The key step is highly enantioselective carbon-hydrogen insertion from a diazoacetate using a chiral dirhodium(II) carboxamidate catalyst. An elimination process essential to the construction has been optimized to avoid intramolecular Friedel-Crafts alkylation.