431935-35-2

Upstream product

• 404848-18-6 methyl (2S)-[(1H-1,2,3-benzotriazol-1-ylmethyl)amino]-3-phenylpropanoate 
• 762-72-1 allyl-trimethyl-silane 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 5162-44-7 1-bromo-4-butene 

Downstream Products

• 1632323-02-4 (2S)-methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopiperidin-1-yl)-3-phenylpropanoate 
• 1632323-03-5 methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopiperidin-1-yl)-3-phenylpropanoate 
• 1632323-00-2 (S)-methyl 2-(2-oxo-5,6-dihydropyridin-1(2H)-yl)-3-phenylpropanoate 
• 1632323-25-1 C₁₇H₂₁NO₃ 

Relevant academic research and scientific papers

Facile N-Derivatization of α-Amino Esters and Amides via Benzotriazolylmethyl Derivatives

α-(N-Substituted amino)esters were prepared in a two-step procedure from available unsubstituted α-amino esters. α-Amino esters are first converted into the corresponding N-benzotriazolylmethyl derivatives; in the second step, the benzotriazole group is substituted by various nucleophiles with or without the presence of a Lewis acid to give substituted α-amino esters in high overall yield under mild conditions with no signs of racemization. Boc-protected amino acids were converted into α-amino amides; subsequent deprotection allowed the conversion into N-substituted derivatives analogously to the α-amino esters, without racemization in high yields under mild conditions.

LiOH-mediated N-monoalkylation of α-amino acid esters and a dipeptide ester using activated alkyl bromides

Selective N-monoalkylation of α-amino esters with activated alkyl bromides was studied using various alkali or alkali earth metal bases. In the production of N-monoalkylated amino ester derivatives and suppression of N,N-dialkylation, lithium hydroxide wa