432022-88-3

Basic information

• Product Name: 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER
• Synonyms: 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER;BENZOIC ACID, 4-BROMO-3,5-DIMETHYL-, METHYL ESTER;Mehtyl 4-broMo-3,5-diMethylbenzoate
• CAS NO: 432022-88-3
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.09714
• Mol File: 432022-88-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 310.8°C at 760 mmHg
• Flash Point: 141.8°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 0.000587mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER(432022-88-3)
• EPA Substance Registry System: 4-BROMO-3,5-DIMETHYL-BENZOIC ACID METHYL ESTER(432022-88-3)

Safety Data

• Hazardous Substances Data: 432022-88-3(Hazardous Substances Data)

Usage

Uses

Methyl 4-Bromo-3,5-dimethylbenzoate is a useful reagent for the preparation of benzylaminopyrazinylcyclopropanecarboxylic acid derivatives for use as GPR40 receptor activity modulators.

InChI:InChI=1/C10H11BrO2/c1-6-4-8(10(12)13-3)5-7(2)9(6)11/h4-5H,1-3H3

Upstream product

• 67-56-1 methanol 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 100189-84-2 2,5-dibromo-1,3-dimethylbenzene 
• 400822-47-1 4-bromo-3,5-dimethylbenzaldehyde 
• 3095-48-5 4-amino-3,5-dimethyl-benzoic acid methyl ester 

Downstream Products

• 1001055-67-9 methyl 4-cyano-3,5-dimethylbenzoate 
• 1268693-26-0 methyl 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 

Relevant articles and documents

Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes

A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.

Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors

The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of 5 confirmed the proposed mode of binding. The potent single