432023-52-4

Upstream product

• 66617-58-1 N-(tert-butoxycarbonyl)-L-phenylalanine benzyl ester 
• 536730-54-8 (S)-N-tert-butoxycarbonyl-N-(methoxymethyl)phenylalanine benzyl ester 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 536730-40-2 (2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 5-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-pentyl ester 
• 536730-39-9 (2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 4-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-butyl ester 
• 536730-55-9 (S)-N-tert-butoxycarbonyl-N-(methoxymethyl)-phenylalanine 2-(2-benzyloxyphenyl)ethyl ester 
• 432023-51-3 (S)-N-tert-butoxycarbonyl-N-(methoxymethyl)phenylalanine 2-(2-hydroxyphenyl)ethyl ester 

Relevant academic research and scientific papers

Control of the enantioselectivity of alkylation of phenylalanine derivatives by regulation of the aggregate structure of chiral enolate intermediates

Two strategies were introduced for the control of enantioselectivity of alkylation of phenylalanine derivatives by regulation of the aggregate structure of chiral enolate intermediates. Use of amino acid-dimers, 6 and 15, was effective to minimize solvent

Enantioselective α-allylation of a phenylalanine derivative under the control of aggregation of a chiral nonracemic enolate

α-Allylation of 3 took place upon treatment with KHMDS followed by allylic halides in 82-87% ee in the absence of external chiral sources. A chiral nonracemic enolate with intramolecular aggregation (D) is expected to be an intermediate.