536730-54-8

Upstream product

• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 66617-58-1 N-(tert-butoxycarbonyl)-L-phenylalanine benzyl ester 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 1376605-40-1 benzyl 4-benzyl-3-(methoxymethyl)-2-oxo-5-phenyloxazolidine-4-carboxylate 
• 536730-40-2 (2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 5-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-pentyl ester 
• 536730-39-9 (2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenylpropionic acid 4-[(2S)-2-(tert-butoxycarbonyl-methoxymethylamino)-3-phenyl-propionyloxy]-butyl ester 
• 536730-55-9 (S)-N-tert-butoxycarbonyl-N-(methoxymethyl)-phenylalanine 2-(2-benzyloxyphenyl)ethyl ester 
• 432023-51-3 (S)-N-tert-butoxycarbonyl-N-(methoxymethyl)phenylalanine 2-(2-hydroxyphenyl)ethyl ester 
• 432023-52-4 (S)-N-tert-butoxycarbonyl-N-(methoxymethyl)phenylalanine 

Relevant academic research and scientific papers

Asymmetric intermolecular conjugate addition of amino acid derivatives via memory of chirality: Total synthesis of manzacidin A

Asymmetric intermolecular conjugate addition of α-amino acid derivatives with 4 via memory of chirality has been developed. The reactions proceeded in up to 98% ee with retention of configuration at the newly formed tetrasubstituted carbon center when R = Me. The product (R = Me) was transformed into manzacidin A.

Control of the enantioselectivity of alkylation of phenylalanine derivatives by regulation of the aggregate structure of chiral enolate intermediates

Two strategies were introduced for the control of enantioselectivity of alkylation of phenylalanine derivatives by regulation of the aggregate structure of chiral enolate intermediates. Use of amino acid-dimers, 6 and 15, was effective to minimize solvent