432029-33-9

Upstream product

• 280771-97-3 1-(1-methylethyl)-4-piperidine carboxylic acid 
• 365462-84-6 2-amino-5-bromo-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide 
• 365462-81-3 2-amino-N-(5-chloro-2-pyridyl)-3-hydroxybenzamide 
• 24115-89-7 3-benzyloxy-2-nitrobenzoic acid 
• 24115-90-0 2-nitro-3-benzyloxybenzoyl chloride 

Relevant academic research and scientific papers

Novel strategy to boost oral anticoagulant activity of blood coagulation enzyme inhibitors based on biotransformation into hydrophilic conjugates

The blood coagulation cascade represents an attractive target for antithrombotic drug development, and recent studies have attempted to identify oral anticoagulants with inhibitory activity for enzymes in this cascade, with particular attention focused on

SUBSTITUTED BENZENE DERIVATIVES OR SALTS THEREOF

There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents for diseases induced by thrombosis or embolism. Effective ingredients are the compounds such as 4'-bromo-2'-[(5-chloro-2-pyridyl)carbamoyl)-6-β-D-galactopyranosyloxy-1-isopropylpiperidine-4-carboxanilide, 2'-(2-acetamido-2-deoxy-β-D-glucopyranosyloxy)-4'-bromo-6'-[(5-chloro-2-pyridyl)carbamoyl]-1-isopropylpiperidine-4-carboxanilide, etc. or salts thereof.