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CB 13 is a synthetic cannabinoid derivative that acts as a potent agonist for both CB1 and CB2 receptors. It has limited brain penetration but holds significant potential as an analgesic for managing chronic pain.

432047-72-8

432047-72-8 Suppliers

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432047-72-8 Usage

Uses

Used in Pharmaceutical Industry:
CB 13 is used as an analgesic agent for the treatment of chronic pain. Its agonistic action on CB1 and CB2 receptors makes it a promising candidate for pain management, particularly in conditions where traditional pain relief methods may be insufficient or less effective.
Used in Research and Development:
CB 13 is also used as a research tool to study the effects and mechanisms of cannabinoid receptors in various physiological and pathological processes. This can lead to the development of new therapeutic strategies and a better understanding of the endocannabinoid system's role in pain management and other conditions.
Used in Synthetic Cannabinoids:
CB 13 is utilized in the development and study of synthetic cannabinoids, which can have potential applications in various medical and therapeutic areas. The study of synthetic cannabinoids like CB 13 can provide insights into the development of more effective and targeted treatments for chronic pain and other conditions.

Biological Activity

Potent, orally active CB 1 /CB 2 receptor agonist with limited brain penetration (EC 50 values are 6.1 and 27.9 nM for CB 1 and CB 2 receptors respectively). Displays antihyperalgesic activity in a rat model of neuropathic pain with no CNS side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 432047-72-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,2,0,4 and 7 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 432047-72:
(8*4)+(7*3)+(6*2)+(5*0)+(4*4)+(3*7)+(2*7)+(1*2)=118
118 % 10 = 8
So 432047-72-8 is a valid CAS Registry Number.

432047-72-8Downstream Products

432047-72-8Relevant academic research and scientific papers

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: A potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration

Dziadulewicz, Edward K.,Bevan, Stuart J.,Brain, Christopher T.,Coote, Paul R.,Culshaw, Andrew J.,Davis, Andrew J.,Edwards, Lee J.,Fisher, Adrian J.,Fox, Alyson J.,Gentry, Clive,Groarke, Alex,Hart, Terance W.,Huber, Werner,James, Iain F.,Kesingland, Adam,La Vecchia, Luigi,Loong, Yvonne,Lyothier, Isabelle,McNair, Kara,O'Farrell, Cathal,Peacock, Marcus,Portmann, Robert,Schopfer, Ulrich,Yaqoob, Mohammed,Zadrobilek, Jiri

, p. 3851 - 3856 (2007)

Selective activation of peripheral cannabinoid CB1 receptors has the potential to become a valuable therapy for chronic pain conditions as long as central nervous system effects are attenuated. A new class of cannabinoid ligands was rationally

NEW USE IN GASTROINTESTINAL DISORDERS

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Page/Page column 12, (2008/06/13)

The present invention relates to the use of a compound of formula I for the inhibition of transient lower esophageal sphincter relaxations. A further aspect of the invention is directed to the use of a compound of formula I for the treatment of gastro-esophageal reflux disease, as well as for the treatment of regurgitation.

Naphthalene derivatives

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, (2008/06/13)

The present invention relates to novel naphthalene derivatives of formula (I), wherein R1, R2, R3 and X are as defined in the description, and preparation thereof. The compounds of formula (I) are useful as pharmaceuticals.