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43215-12-9

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43215-12-9 Usage

Description

2-(chloromethyl)-1-(methylsulfonyl)-1H-benzimidazole is a benzimidazole derivative with the molecular formula C9H9ClN2O2S. It features a chlorine atom and a methylsulfonyl group, which contribute to its versatile chemical properties. 2-(chloromethyl)-1-(methylsulfonyl)-1H-benzimidazole has potential applications in the pharmaceutical and agrochemical industries, making it a valuable intermediate in the synthesis of various drugs and agrochemicals. Its unique structure and functional groups also make it a promising building block for creating new chemical compounds with specific properties and functions.

Uses

Used in Pharmaceutical Industry:
2-(chloromethyl)-1-(methylsulfonyl)-1H-benzimidazole is used as an intermediate in the synthesis of pharmaceutical drugs for its versatile chemical properties and potential biological activity. It can be incorporated into drug molecules to enhance their therapeutic effects or improve their pharmacokinetic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(chloromethyl)-1-(methylsulfonyl)-1H-benzimidazole is used as an intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and functional groups can be utilized to develop new agrochemicals with improved efficacy and selectivity.
Used in Research and Development:
2-(chloromethyl)-1-(methylsulfonyl)-1H-benzimidazole is used as a research compound for exploring its biological activity and potential applications in various fields. Its unique structure and functional groups make it an interesting candidate for studying its interactions with biological targets and evaluating its potential as a therapeutic agent or chemical probe.
Used in the Creation of New Chemical Compounds:
Due to its unique structure and functional groups, 2-(chloromethyl)-1-(methylsulfonyl)-1H-benzimidazole can be used as a building block for the synthesis of new chemical compounds with specific properties and functions. This can lead to the development of novel materials, catalysts, or other specialty chemicals with potential applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 43215-12-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,2,1 and 5 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 43215-12:
(7*4)+(6*3)+(5*2)+(4*1)+(3*5)+(2*1)+(1*2)=79
79 % 10 = 9
So 43215-12-9 is a valid CAS Registry Number.

43215-12-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(chloromethyl)-1-methylsulfonylbenzimidazole

1.2 Other means of identification

Product number -
Other names 2(Chloromethyl)-1-(methylsulfonyl)benzimidazol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:43215-12-9 SDS

43215-12-9Downstream Products

43215-12-9Relevant articles and documents

Synthesis and antifungal activity of 2-chloromethyl-1 H -benzimidazole derivatives against phytopathogenic fungi in vitro

Bai, Yu-Bin,Zhang, An-Ling,Tang, Jiang-Jiang,Gao, Jin-Ming

, p. 2789 - 2795 (2013/06/04)

A series of 35 benzimidazole derivatives were synthesized from 2-chloromethyl-1H-benzimidazole in good yields. Their structures were characterized by 1H and 13C NMR and HRESIMS. Antifungal activities of all of the synthesized compounds were evaluated against five phytopathogens fungi (Cytospora sp., Colletotrichum gloeosporioides, Botrytis cinerea, Alternaria solani, and Fusarium solani) using the mycelium growth rate method. Compound 4m displayed strong growth inhibition of C. gloeosporioides, A. solani, and F. solani with IC50 of 20.76, 27.58, and 18.60 μg/mL, respectively. Selective inhibition of B. cinerea instead of the other fungal pathogenes was observed with 7f (IC50 of 13.36 μg/mL), comparable to that of positive control, a commercial agricultural fungicide hymexazol (IC50 of 8.92 μg/mL). Compound 5b exhibited remarkable antifungal properties against Cytospora sp., C. gloeosporioides, B. cinerea, and F. solani with IC50 values of 30.97, 11.38, 57.71, and 40.15 μg/mL, respectively; among the target fungi, 5b was the most active compound and superior to the reference against C. gloeosporioides alone. Structure-activity relationship (SAR) data of these compounds are as follows: (1) introduction of the chlorine atom on para-position in the benzene ring help to increase activity (4f vs 4c; 7f vs 7n), (2) the sulfonyl group is critical for the inhibition of C. gloeosporioides (5b and 5c vs 5a), and (3) the unsubstituted benzene ring improve activity (4m vs 4n, 4e and 4a). Thus, compounds 5b, 4m, and 7f emerged as a new leading structure for the development of new fungicides.

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