43221-69-8

Upstream product

• 3245-92-9 N-(3-hydroxypropyl)-4-methylbenzamide 
• 104-85-8 para-methylbenzonitrile 
• 156-87-6 propan-1-ol-3-amine 
• 874-60-2 4-methyl-benzoyl chloride 
• 80254-26-8 Trifluoro-methanesulfonate14-[3-(4-methyl-benzoylamino)-propyl]-7-phenyl-5,6,8,9-tetrahydro-dibenzo[c,h]acridinium; 
• 72320-38-8 3-azidopropan-1-ol 
• 104-87-0 4-methyl-benzaldehyde 

Relevant academic research and scientific papers

A 2 - substituted oxazoline or 2 - substituted piperazine synthetic method (by machine translation)

The invention discloses a method for synthesizing 2 - substituted oxazoline or 2 - substituted oxazine new method, by nitrile and amino ethanol or 3 - amino - 1 - propanol as raw material, in the absence of solvent, can be used for the recycling of the sulfur to induce synthesis of 2 - substituted oxazoline and 2 - substituted piperazine. The method of the invention has low cost, simple reaction process, mild reaction conditions, the reaction time is short, the yield and the like, is suitable for the industrial generation. (by machine translation)

Microwave-Assisted Synthesis of 2-Aryl-2-oxazolines, 5,6-Dihydro-4H-1,3-oxazines, and 4,5,6,7-Tetrahydro-1,3-oxazepines

The first general procedure for the synthesis of 5- to 7-membered cyclic iminoethers by microwave-assisted cyclization of ω-amido alcohols promoted by polyphosphoric acid (PPA) esters is presented. 2-Aryl-2-oxazolines and 5,6-dihydro-4H-1,3-oxazines were efficiently prepared using ethyl polyphosphate/CHCl3. Trimethylsilyl polyphosphate in solvent-free conditions allowed for the synthesis of hitherto-unreported 4,5,6,7-tetrahydro-1,3-oxazepines. The method involves good to excellent yields and short reaction times.The reaction mechanism and the role of PPA esters were investigated in a chiral substrate.

S-Co(II) cascade catalysis: Cyclocondensation of aromatic nitriles with alkamine

A solvent-free S/Co(NO3)2 cascade catalyzed cyclocondensation reaction of aromatic nitriles with 3-amino-1-propanol or 2-aminoethanol has been successfully developed under thermal and microwave conditions. By this two-component protocol, mono- and bis-oxazines and oxazolines were selectively synthesized both in good to excellent yields and short reaction times. This catalytic system exhibits excellent chemoselectivity, and can be reused at least seven times without significant loss of activity in subsequent reactions.

Reactions of N-Benzyl- and N-Benzylidene-alkanolamines with Bromine: Formation of 1,3-Oxazolidines, 1,3-Oxazinanes, 4,5-Dihydro-1,3-oxazoles and 5,6-Dihydro-4H-1,3-oxazines

N-Methylbenzylamines react with bromine in acetonitrile to form N-benzylidenemethylamines.Under similar conditions 2-benzylaminoethanols and 3-benzylaminopropan-1-ols afford 3-benzyl-2-phenyl-1,3-oxazolidines and 3-benzyl-2-phenyl-1,3-oxazinanes, respectively. 2-Benzylidineaminoethanols and 3-benzylideneaminopropan-1-ols likewise give 2-aryl-4,5-dihydro-1,3-oxazoles and 2-aryl-5,6-dihydro-4H-1,3-oxazines, respectively.When N-benzylidenemethylamine is treated with bromine in the presence of alcohols, benzaldehyde acetals are obtained.

TRANSFORMATIONS OF PYRIDINIUMS DERIVED FROM AMINO-ALCOHOLS AND FROM DIAMINES

Pyridiniums derived from amino alcohols cyclise to ethers or rearrange to aldehydes on heating.Monopyridiniums from diamines can be acylated or converted into ureas or thioureas: these products cyclise on heating in solution to give dihydro-thiazoles, -4H-thiazines, -oxazoles, -4H-oxazines, or tetrahydro-3H-thiazepines.