43228-10-0

Upstream product

• 80-63-7 methyl 2-chloroacrylate 
• 74-93-1 methylthiol 
• 4519-46-4 methyl 2-bromoacrylate 
• 20444-25-1 2-Chlor-3-(methylthio)propansaeure-methylester 
• 121-44-8 triethylamine 
• 68-12-2 N,N-dimethyl-formamide 
• 61366-76-5 methyl β-(methylthio)propionate 

Downstream Products

• 43228-19-9 2-Methylsulfanyl-3-(2-oxo-cyclohexyl)-propionic acid methyl ester 
• 118751-70-5 (2R,5S)-2-Ethoxycarbonylamino-5-methyl-1-methylsulfanyl-cyclohex-3-enecarboxylic acid methyl ester 
• 115047-81-9 methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl><2-carbomethoxy-2(RS)-(methylthio)-1-ethyl>phosphinate 
• 5259-65-4 4-methyl-3-cyclohexen-1-one 
• 75337-05-2 4-methyl-2-cyclohexenone 
• 82297-14-1 methyl-3 mehylthio-1 cyclohexene-3 carboxylate de methyle-1 
• 82297-11-8 methyl-4 mehylthio-1 cyclohexene-3 carboxylate de methyle-1 
• 109240-15-5 acide methyl-3 thiomethyl-1 cyclohexene-3 carboxylique-1 
• 109240-14-4 acide methyl-4 thiomethyl-1 cyclohexene-3 carboxylique-1 
• 1184174-33-1 1-benzyl-3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester 
• 1093063-62-7 (S)-3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester L-tartrate 
• 77-73-6 endo-<2+4>-Dicyclopentadien 
• 82297-19-6 (1S,4S)-2-Methylsulfanyl-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester 
• 118751-75-0 C₁₅H₂₀O₂S 

Relevant academic research and scientific papers

(S)-N-(3-(6-ISOPROPOXYPYRIDIN-3-YL)-1H-INDAZOL-5-YL)-1-(2-(4-(4-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)-3,6-DIHYDROPYRIDIN-1(2H)-YL)-2-OXOETHYL)-3- (METHYLTHIO)PYRROLIDINE-3-CARBOXAMIDE COMPOSITIONS FOR PHARMACEUTICAL PREPARATIONS

A composition comprising (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)- 1-(2(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide and hypromellose acetate succinate for pharmaceutical preparations, especially capsule preparations.

[3+2] Cycloaddition-mediated synthesis of 3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester

1,3-Dipolar cycloaddition reactions are fundamental processes in organic chemistry. Herein we report [3+2] annulation of thiomethylacrylate 2 and azomethine ylide precursor 3 towards the synthesis of novel 3-methylsulfanyl-pyrrolidine 5. Alternatively, we

COMPOUNDS THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, and solvates thereof. Q is a tetrahydopyridinyl ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

DIENOPHILIE DES OLEFINES CAPTODATIVES - VI SYNTHESES ET CYCLOADDITIONS DE DIELS-ALDER DES α-ALKYLTHIO-ACRYLATES D'ALKYLE AVEC LE CYCLOPENTADIENE: INFLUENCE DES FACTEURS STERIQUES SUR LA REACTIVITE ET SUR LA STEREOSELECTIVITE

The Diels-Alder reactions of cyclopentadiene with a series of four α-alkylthio-alkyl acrylates were investigated.Although slightly slower than the reactions of unsubstituted alkyl acrylates, the spontaneous cycloadditions of these captodative olefins occur at room temperature affording adducts in excellent yield.The steric effect of the ester function is found to be more important in determining the dienophilic reactivity than the endo/exo ratios of the adducts and increase in the size of the alkylthio group reduces the endo selectivity of that group from 66-69percent (for methylthio) to 25-22percent (for tertiobutylthio group).The aluminium trichloride complexed methoxycarbonyl group leads to a very high endo-stereoselectivity (97percent) of that group.