432506-50-8Relevant academic research and scientific papers
Substituted Carbazoles-A New Class of Anthelmintic Agent
Rennison, David,Gueret, Stephanie M.,Laita, Olivia,Bland, Ross J.,Sutherland, Ian A.,Boddy, Ian K.,Brimble, Margaret A.
, p. 1268 - 1276 (2016/11/25)
A series of novel carbazoles were synthesized based on structural modifications to lead carbazole 1 (EC100≤2.5M against Haemonchus contortus in vitro), which was revealed in a small molecule screening program as a potentially promising platform for the development of new anthelmintic drugs. Subsequently, analogues 19, 21, 41, 42 (EC100≤ 1.25M, all), and 39 (EC100≤0.625M) were demonstrated to exhibit enhanced in vitro anthelmintic activity over the lead structure, with compound 39 also being shown to be active in vivo against Heligmosomoides polygyrus.
HEPATITIS C VIRUS ENTRY INHIBITORS
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Page/Page column 57, (2010/11/30)
The present invention relates to the use of tricyclic diphenylamine derivative compounds for prevention and/or treatment of Hepatitis C virus (HCV) infection by inhibiting HCV entry into permissive cells.
Carbazole neuropeptide Y5 antagonists
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, (2008/06/13)
Carbazoles of the formula which are effective in treating conditions associated with neuropeptide Y-5 neurotransmission.
