432512-66-8Relevant articles and documents
N-Heterocyclic Carbene-Catalyzed Atroposelective Annulation for Access to Thiazine Derivatives with C?N Axial Chirality
Li, Tingting,Mou, Chengli,Qi, Puying,Peng, Xiaolin,Jiang, Shichun,Hao, Gefei,Xue, Wei,Yang, Song,Hao, Lin,Chi, Yonggui Robin,Jin, Zhichao
, p. 9362 - 9367 (2021)
A catalytic atroposelective cycloaddition reaction between thioureas and ynals is developed. This reaction features the first NHC-catalyzed addition of thioureas to acetylenic acylazolium intermediates to eventually set up C?N axial chirality with excellent optical purities. The obtained axially chiral thiazine derivative products bear multiple functional groups and are feasible for further transformations.