432554-92-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridinemethanol,6-ethenyl-(9CI) is used as a building block for the production of pharmaceuticals for its potential biological activity and unique structure.
Used in Agrochemical Industry:
3-Pyridinemethanol,6-ethenyl-(9CI) is used as a building block for the production of agrochemicals due to its potential applications in the development of new drugs or treatment methods.
Used in Specialty Chemicals Industry:
3-Pyridinemethanol,6-ethenyl-(9CI) is used as a building block for the production of specialty chemicals for its unique structure and properties.
Used in Organic Synthesis:
3-Pyridinemethanol,6-ethenyl-(9CI) is used as a reagent in various chemical reactions for its potential applications in the development of new drugs or treatment methods.

Upstream product

• 21543-49-7 2-Chloro-5-hydroxymethylpyridine 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 122306-01-8 2-bromo-5-(hydroxymethyl)pyridine 

Downstream Products

• 1228957-87-6 C₂₆H₂₀Cl₂N₄O₃ 

Relevant academic research and scientific papers

Isoxazolines as Therapeutic Agents

The present invention provides compound of Formula (I) biologically active metabolites, pro-drugs, isomers, stereoisomers, solvates, hydrates and pharmaceutically acceptable salts thereof wherein the variables are defined herein. The compounds of the invention are useful for treating immunological conditions.

Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCθ inhibitors

Analog 8, a 3-pyridinecarbonitrile with an (E)-2-{6-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl}vinyl group at C-5, had an IC50 value of 1.1 nM for the inhibition of PKCθ and potently blocked the production of IL-2 in both stimulated murine T cells (IC50 = 34 nM) and human whole blood (IC50 = 500 nM).

Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors

The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC50 values of 2.1 and 58 nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study.

5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS

Described herein are compounds of formula I: wherein G is and pharmaceutically acceptable salts thereof, wherein J, X, R1, R2, R11, R12' and p are as defined herein. Also provided herein are methods of making the compounds of formula I, and methods of using these compounds for inhibiting or treating a pathological condition or disorder linked to or mediated by a protein kinase in a mammal.