4328-04-5Relevant articles and documents
New cardiolipin analogs synthesized by phospholipase D-catalyzed transphosphatidylation
Mueller, Anna O.,Mrestani-Klaus, Carmen,Schmidt, Juergen,Ulbrich-Hofmann, Renate,Dippe, Martin
, p. 787 - 793 (2012)
Cardiolipin (CL) and related diphosphatidyl lipids are hardly accessible because of the complexity of their chemical synthesis. In the present paper, the transphosphatidylation reaction catalyzed by phospholipase D (PLD) from Streptomyces sp. has been proven as an alternative enzyme-assisted strategy for the synthesis of new CL analogs. The formation of this type of compounds from phosphatidylcholine was compared for a series of N- and C2-substituted ethanolamine derivatives as well as non-charged alcohols such as glycerol and ethylene glycol. The rapid exchange of the choline head group by ethanolamine derivatives having a low molecular volume (diethanolamine and serinol) gave rise to an efficient production of the corresponding CL analogs. In contrast, the yields were comparably low in the reaction with bulky nitrogenous acceptor alcohols (triethanolamine, tris(hydroxymethyl)aminomethane, tetrakis(hydroxyethyl)ammonium) or the non-charged alcohols. Therefore, a strong dependence of the conversion of the monophosphatidyl to the diphosphatidyl compound on steric parameters and the head group charge was concluded. The enzyme-assisted strategy was used for the preparation of purified diphosphatidyldiethanolamine and diphosphatidylserinol.
Terephthalate quaternary ammonium salt as well as preparation method and application thereof
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Paragraph 0107-109, (2019/03/08)
The invention relates to terephthalate quaternary ammonium salt as well as a preparation method and application thereof. The terephthalate quaternary ammonium salt is prepared by carrying out condensation reaction on quaternary ammonium salt with hydroxyethyl groups and phthaloyl dichloride. The preparation method for the terephthalate quaternary ammonium salt is simple, and the prepared terephthalate quaternary ammonium salt has certain ionic conductivity and can be used as an organic electrolyte and a polymer nucleating agent.
ORGANIC ELECTROLYTE COMPOUNDS FOR REDOX-FLOW BATTERIES
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Paragraph 0105; 0106, (2018/04/13)
The present invention relates to redox electrolyte compounds. The present invention further relates to a redox-flow battery wherein one of the catholyte and the anolyte, or both, has the redox electrolyte compound of the invention. The present invention further relates to the method of controlling the redox-flow battery and its use for energy storage.
Effect of hydrogen bond of hydroxyl-functionalized ammonium ionic liquids on cycloaddition of CO2
Cheng, Weiguo,Xiao, Benneng,Sun, Jian,Dong, Kun,Zhang, Peng,Zhang, Suojiang,Ng, Flora T.T.
, p. 1416 - 1419 (2015/03/04)
A synergistic effect of the hydrogen bond on the cycloaddition of CO2 and epoxides to form cyclic carbonates was investigated through experimental study and characterization. A highly effective homogeneous system of hydroxyl-functionalized quaternary ammonium ionic liquids with a different number of the hydroxyl group in the cation was developed for the fixation of CO2 to form cyclic carbonates. A mechanism via the hydrogen bond activation for the cycloaddition was proposed based on both experimental data and modeling. This research enhances the understanding of the promotion of reaction via hydrogen bonding and forms the basis for the rational design of catalytic systems for the fixation of CO2 into organic compounds.
4-HYDROXY BENZOATE DERIVATIVES FOR USE IN THE TREATMENT OF INFECTION, INFLAMMATION OR PAIN
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Page/Page column 12, (2009/01/23)
The invention provides a compound of the general formula (I) for use in the topical treatment of infection, inflammation and/or pain: wherein R1 independently represents a methylene group, an ethylene group or a straight or branched chain C3 to C6 alkylene group; R2 independently represents a hydrogen atom, a methyl group, an ethyl group or a straight or branched chain C3 to C20 alkyl group; x represents 0 or an integer from 1 to 4 and y represents 0 or an integer from 1 to 4, wherein the sum of x and y is 4; and Z represents a hydrogen atom or (HOR1)yR2XN⊕; compositions comprising the compound; use of the compound in the manufacture of a medicament; and methods of medical treatment comprising the topical application of the compound.