433-05-6

Usage

Uses

Used in Pharmaceutical Industry:
4-Fluoro-N-propylbenzenesulfonamide is used as a building block for the synthesis of various pharmaceuticals due to its potential biological activity and its role as a starting material in the development of new therapeutic agents. Its unique chemical structure allows it to be a key component in creating organic compounds with pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Fluoro-N-propylbenzenesulfonamide is employed as a precursor in the synthesis of agrochemicals, contributing to the development of new compounds with applications in crop protection and pest management. Its versatility in chemical reactions makes it a useful intermediate for creating effective and targeted agrochemical products.
Used in Medicinal Chemistry Research:
4-Fluoro-N-propylbenzenesulfonamide is utilized as a research compound in medicinal chemistry, where it serves as a starting material for exploring and creating novel therapeutic agents. Its incorporation into various chemical structures aids researchers in understanding its potential interactions with biological targets and its efficacy in treating specific conditions.
Overall, 4-Fluoro-N-propylbenzenesulfonamide's applications span across different industries, highlighting its importance as a versatile chemical intermediate with significant potential in the development of new pharmaceuticals, agrochemicals, and other organic compounds with therapeutic or protective properties.

Upstream product

• 107-10-8 propylamine 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Relevant academic research and scientific papers

Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

The nucleotide exchange factor Son of Sevenless (SOS) catalyzes the activation of RAS by converting it from its inactive GDP-bound state to its active GTP-bound state. Recently, we have reported the discovery of small-molecule allosteric activators of SOS1 that can increase the amount of RAS-GTP in cells. The compounds can inhibit ERK phosphorylation at higher concentrations by engaging a feedback mechanism. To further study this process, we sought different chemical matter from an NMR-based fragment screen using selective methyl labeling. To aid this process, several Ile methyl groups located in different binding sites of the protein were assigned and used to categorize the NMR hits into different classes. Hit to lead optimization using an iterative structure-based design paradigm resulted in compounds with improvements in binding affinity. These improved molecules of a different chemical class increase SOS1cat-mediated nucleotide exchange on RAS and display cellular action consistent with our prior results.

Transition-Metal-Free One-Step Synthesis of Ynamides

A robust transition-metal-free one-step strategy for the synthesis of ynamides from sulfonamides and (Z)-1,2-dichloroalkenes or alkynyl chlorides is presented. This method is not only effective for internal ynamides but also amenable for terminal ynamides. Various functional groups, even the vinyl moiety, are compatible, and thus, this strategy offers the opportunity for further functionalization.