433217-44-8Relevant academic research and scientific papers
Synthesis of deuterated-BCX-1777, a potent inhibitor of purine nucleoside phosphorylase
Kezar III, Hollis S.,Hutchison, Tracy L.,Tyler, Peter C.,Morris Jr., Philip E.
, p. 71 - 78 (2002)
BCX-1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme-catalyzed C-N bond cleavage of nucleosides. BCX-1777 is a slow-onset, tight-binding inh
Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects
Murkin, Andrew S.,Tyler, Peter C.,Schramm, Vern L.
, p. 2166 - 2167 (2008/09/18)
The binding of [5′-3H]inosine to human purine nucleoside phosphorylase results in an equilibrium binding isotope effect (BIE) of 1.5%, and transition state formation causes an intrinsic KIE of 4.7%. These values reflect atomic vibrational disto
