433217-46-0Relevant academic research and scientific papers
Synthesis of deuterated-BCX-1777, a potent inhibitor of purine nucleoside phosphorylase
Kezar III, Hollis S.,Hutchison, Tracy L.,Tyler, Peter C.,Morris Jr., Philip E.
, p. 71 - 78 (2007/10/03)
BCX-1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme-catalyzed C-N bond cleavage of nucleosides. BCX-1777 is a slow-onset, tight-binding inh
