433287-50-4Relevant academic research and scientific papers
Peptide-Catalyzed Fragment Couplings that Form Axially Chiral Non-C2-Symmetric Biaryls
Coombs, Gavin,Sak, Marcus H.,Miller, Scott J.
supporting information, p. 2875 - 2880 (2020/01/24)
We have demonstrated that small, modular, tetrameric peptides featuring the Lewis-basic residue β-dimethylaminoalanine (Dmaa) are capable of atroposelectively coupling naphthols and ester-bearing quinones to yield non-C2-symmetric BINOL-type scaffolds with good yields and enantioselectivity. The study culminates in the asymmetric synthesis of backbone-substituted scaffolds similar to 3,3′-disubstituted BINOLs, such as (R)-TRIP, with good (94:6 e.r.) to excellent (>99.9:0.1 e.r.) enantioselectivity after recrystallization, and a diastereoselective net arylation of the minimally modified nonsteroidal anti-inflammatory drug (NSAID) naproxen.
Catalytic asymmetric synthesis of aryl diphenol the axis chiral is joint method
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Paragraph 0049; 0050; 0051; 0060; 0061, (2017/10/31)
The invention discloses a method for catalyzing asymmetrically synthesized axially chiral biaryl diphenol. In an organic solvent, chiral phosphoric acid is taken as a catalyst, a compound shown in a formula III is obtained by reaction on a compound shown
Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2-Naphthols
Chen, Ye-Hui,Cheng, Dao-Juan,Zhang, Jian,Wang, Yong,Liu, Xin-Yuan,Tan, Bin
supporting information, p. 15062 - 15065 (2015/12/18)
The first phosphoric acid-catalyzed asymmetric direct arylative reactions of 2-naphthols with quinone derivatives have been developed, providing efficient access to a class of axially chiral biaryldiols in good yields with excellent enantioselectivities u
Blennione, a green aminobenzoquinone derivative from Lactarius blennius
Spiteller, Peter,Steglich, Wolfgang
, p. 725 - 727 (2007/10/03)
A green pigment, blennione (1), was isolated from fruit bodies of the toadstool Lactarius blennius. Its structure was established by 2D NMR methods and confirmed by a biomimetic synthesis. Compound 1 represents a diphenylquinone derivative, which may be formed biosynthetically from two 3,6-dihydroxy-anthranilic acid units.
