4333-66-8Relevant academic research and scientific papers
A convenient and highly regio and stereoselective method for the synthesis of (E)-3-alkylidene isobenzofuran-1(3H)-ones (phthalides)
Mukhopadhyay, Rupa,Kundu, Nitya G
, p. 9475 - 9480 (2007/10/03)
2-Iodobenzyl alcohol on treatment with acetylenic carbinols in the presence of a palladium catalyst and copper(I) iodide as a co-catalyst afforded disubstituted alkynes. Jones oxidation of the disubstituted alkynes led to (E)-3-alkylidene isobenzofuran-1(
Palladium-catalysed heteroannulation with terminal alkynes: Synthesis of phthalides
Kundu, Nitya G.,Pal, Manojit,Nandi, Bidisha
, p. 561 - 568 (2007/10/03)
The palladium-copper-catalysed heteroannulation of o-iodobenzoic acid 3 with terminal alkynes 4-18 leads to the synthesis of (Z)-3-alkylidenephthalides 19-33 as the major products. In certain cases, the formation of isocoumarins 34-37 is also observed.
A Convenient Synthesis of 3-Phenacylidenephthalides
Hori, Kimihiko,Takaishi, Naotake
, p. 1791 - 1792 (2007/10/02)
3-Phenacylidenephthalides were prepared by the dehydration of 2-(1,3-dioxo-3-phenylpropyl)benzoic acids, obtained in turn by the condensation of phthalic anhydride with acetophenones.
