433305-00-1Relevant academic research and scientific papers
METHOD OF FLUORINATION
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Page/Page column 16, (2008/06/13)
A method of fluorination comprising reacting monosaccharides, oligosaccharides, polysaccharides, composite saccharides formed by bonding of these saccharides with proteins and lipids and saccharides having polyalcohols, aldehydes, ketones and acids of the polyalcohols, and derivatives and condensates of these compounds with a fluorinating agent represented by general formula (I) thermally or under irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region. In accordance with the method, the fluorination at a selected position can be conducted safely at a temperature in the range of 150 to 200°C where the reaction is difficult in accordance with conventional methods. The above method comprising the irradiation with microwave or an electromagnetic wave having a wavelength around the microwave region can be applied to substrates other than saccharides. When a complex compound comprising HF and a base is reacted under irradiation with microwave, fluorination at a specific position which is difficult in accordance with conventional methods proceeds highly selectively, efficiently in a short time and safely.
Synthesis of fluorinated cycloalkyl N-phenylcarbamates and their microbial defluorination/oxygenation by Beauveria bassiana
Haufe, Guenter,Pietz, Sylke,Woelker, Doerthe,Froehlich, Roland
, p. 2166 - 2175 (2007/10/03)
Earlier investigations showed that cycloalkyl N-phenylcarbamates were hydroxylated by the fungus Beauveria bassiana predominantly in the 4-position relative to the electron-rich substituent. In cases involving fluorinated methylene groups potentially capable of hydroxylation, however, defluorination and formation of a ketone was observed. The formation of the ketone can be explained by primary hydroxylation to forman unstable geminal fluorohydrin, which is subsequently dehydrofluorinated. Wiley-VCH Verlag GmbH & Co. KGaAA, 69451 Weinheim, Germany, 2003.
Effective fluorination reaction with Et3N·3HF under microwave irradiation
Inagaki, Tomotake,Fukuhara, Tsuyoshi,Hara, Shoji
, p. 1157 - 1159 (2007/10/03)
Fluorination reaction of epoxides and alkyl mesylates can be effectively achieved by reaction with Et3N·3HF under microwave irradiation. The reaction time could be greatly reduced compared to the reaction under thermal conditions. The reactions
Synthesis of optically active vicinal fluorohydrins by lipase-catalyzed deracemization
Woelker, Doerthe,Haufe, Guenter
, p. 3015 - 3021 (2007/10/03)
Three microbial lipases have been used to deracemize trans-2-fluorocycloalkanols 2 both by hydrolysis of the corresponding acetates 3 or chloroacetates 4 and by esterification of the fluorohydrins 2 using vinyl acetate and vinyl chloroacetate, respectivel
