433307-98-3

Basic information

• Product Name: C₁₈H₁₄O₄
• CAS NO: 433307-98-3
• Molecular Weight: 294.307
• Mol File: 433307-98-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₄O₄(433307-98-3)
• EPA Substance Registry System: C₁₈H₁₄O₄(433307-98-3)

Safety Data

• Hazardous Substances Data: 433307-98-3(Hazardous Substances Data)

Upstream product

• 64231-10-3 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Anti-influenza drug discovery: Structure-activity relationship and mechanistic insight into novel angelicin derivatives

By using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza A. (H1N1) virus induced cytopathic effect in Madin-Darby canine kidney cell culture in low micromolar range. Detailed structure-activity relationship studies of 6a revealed that the angelicin scaffold is essential for activity in pharmacophore B, while meta-substituted phenyl/2-thiophene rings are optimal in pharmacophore A and C. The optimized lead 4-methyl-9-phenyl-8-(thiophene-2-carbonyl)-furo[2,3-h] chromen-2-one (8g, IC50 = 70 nM) showed 64-fold enhanced activity compared to the high throughput screening (HTS) hit 6a. Also, 8g was found effective in case of influenza A (H3N2) and influenza B virus strains similar to approved anti-influenza drug zanamivir (4). Preliminary mechanistic studies suggest that these compounds act as anti-influenza agents by inhibiting ribonucleoprotein (RNP) complex associated activity and have the potential to be developed further, which could form the basis for developing additional defense against influenza pandemics.