433330-75-7

Upstream product

• 433330-68-8 3,4-bis-(4-chloro-phenyl)-4-oxo-butyric acid ethyl ester 
• 25026-34-0 4-chlorophenacetyl chloride 
• 51490-05-2 1,2-bis(4-chlorophenyl)ethanone 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 70777-03-6 6-chloro-3,4-bis-(4-chloro-phenyl)-pyridazine 
• 70769-41-4 5,6-bis-(4-chloro-phenyl)-2H-pyridazin-3-one 
• 433330-82-6 5,6-bis-(4-chloro-phenyl)-4,5-dihydro-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Mono- and di-substituted 5,6-diphenyl-3-alkylaminopyridazines active as ACAT inhibitors

A series of mono- or di-para-substituted 5,6-diphenyl-3-alkylaminopyridazines were synthesized and their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. The compound which combines a chlorine atom on the 6-phenyl ring and a n-hexylamino chain showed a significant enhancement of activity with respect to the unsubstituted derivative. Attempts to correlate the activity of the compounds to their structural features, also through theoretical calculations, are reported.