433684-74-3Relevant academic research and scientific papers
Control of tandem isomerizations: Flow-assisted reactions of: O -lithiated aryl benzyl ethers
Lee, Hyune-Jea,Kim, Heejin,Yoshida, Jun-Ichi,Kim, Dong-Pyo
supporting information, p. 547 - 550 (2018/01/19)
Tandem chemical changes are often difficult to control at will, because they proceed rapidly through multiple unstable reactive intermediates. It is desirable to develop a novel method for controlling such tandem changes to obtain desired products with high selectivity. Herein, we report a flow microreactor platform for controlling tandem isomerizations of o-lithiated aryl benzyl ethers based on precise residence time control.
On the Reactivity of o-Lithioaryl Ethers: Tandem Anion Translocation and Wittig Rearrangement
Barluenga, Jose,Fananas, Francisco J.,Sanz, Roberto,Marcos, Cesar,Trabada, Marta
, p. 1587 - 1590 (2007/10/03)
(matrix presented) Allyl and benzyl 2-lithioaryl ethers, generated by bromine-lithium exchange in THF, undergo a new tandem anion translocation-[1,2]-Wittig rearrangement allowing the isolation of the corresponding benzylic alcohols.
