433712-56-2Relevant academic research and scientific papers
Metal-free synthesis of sterically crowded biphenyls by direct Ar-H substitution in alkyl benzenes
Dichiarante, Valentina,Fagnoni, Maurizio,Albini, Angelo
, p. 6495 - 6498 (2008/09/16)
(Chemical Equation Presented) Four's definitely a crowd: The chemoselective activation of Ar-H bonds in methylbenzenes by treatment with photogenerated phenyl cations allowed the synthesis of sterically crowded biphenyl compounds, including tetra-ortho-substituted biphenyls, by intermolecular cross-coupling (see scheme). This method is an appealing metal-free alternative to widely used transition-metal catalysis. TFE = 2,2,2-trifluoroethanol.
