4338-65-2

Upstream product

• 108-31-6 maleic anhydride 
• 106-42-3 para-xylene 
• 6315-21-5 2-(4-methylbenzyl)succinic acid 
• 4484-74-6 4-methylbenzyl iodide 
• 502610-55-1 diethyl 2-acetyl-2-(4-methylbenzyl)succinate 

Downstream Products

• 101794-65-4 6-methyl-1,2,3,4-tetrahydro-[2]naphthaldehyde-(2,4-dinitro-phenylhydrazone) 
• 111719-45-0 Phenylurethan des 6-Hydroxy-2-methyl-9-aethyl-6.7-dihydro-5H-benzocycloheptens 
• 102012-30-6 Phenylurethan des 6-Hydroxy-2.9-dimethyl-6.7-dihydro-5H-benzocycloheptens 
• 102597-06-8 Phenylurethan des 6-Hydroxy-2-methyl-9-aethyl-6.7.8.9-tetrahydro-5H-benzocycloheptens 
• 102156-40-1 Phenylurethan des 6-Hydroxy-2.9-dimethyl-6.7.8.9-tetrahydro-5H-benzocycloheptens 
• 109556-42-5 Phenylurethan des 5-Hydroxy-3-methyl-6.7-dihydro-5H-benzocycloheptens 
• 110048-14-1 7-methyl-3-(toluene-4-sulfonyloxymethyl)-3,4-dihydro-2H-naphthalen-1-one 
• 101742-95-4 7-Methyl-3-hydroxymethyl-1-phenyl-tetralin 
• 110180-43-3 7-Methyl-1-phenyl-2,3-methylen-tetralol-⁽¹⁾ 
• 109393-68-2 7-Methyl-1-phenyl-3-hydroxymethyl-3,4-dihydro-naphthalin 

Relevant academic research and scientific papers

INDANE DERIVATIVES FOR MALODOR COUNTERACTION

The present invention relates to the field of malodor counteraction. More particularly, it concerns malodor masking ingredient having an indane moiety (as defined in formula (I)), as well as malodor masking compositions comprising such ingredients.

Metal-free direct alkylation of unfunctionalized allylic/benzylic sp3 C-H bonds: Via photoredox induced radical cation deprotonation

Despite notable recent efforts, a catalytic and convenient strategy for the direct alkylation of unactivated allylic or benzylic sp3 C-H bonds remains a formidable challenge facing the synthesis community. We herein report an unprecedented allylic/benzylic alkylation using only an organo-photoredox catalyst, which enables coupling of a broad scope of alkenes/arenes and electron-deficient alkenes in an atom-and redox-economic manner. A photoredox induced alkene/arene radical cation deprotonation is proposed to smoothly generate the key allylic and benzylic radical intermediates. It represents the first C-C bond formation via radical cation deprotonation under visible light conditions. The resulting products can be easily scaled up and directly converted to γ,δ-unsaturated or α,β-diaryl-acids,-esters,-amides,-pyrazoles,-isoxazoles, as well as lactones, which enables this mild and selective sp3 C-H alkylation to rapidly access complex bioactive molecules.

A practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid, an antirheumatic agent (part 1).

An efficient and practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (1), a new antirheumatic drug, has been developed. The intermediate, 2-methylene-4-(4-methylphenyl)-4-oxobutanoic acid (2), was prepared by Friedel-Crafts acylation of toluene with itaconic anhydride (3) in the presence of aluminum trichloride and nitrobenzene in 63% yield without silica gel column purification. Compound 1 was prepared by Michael addition of 2 with thioacetic acid (4) in 74% yield. Overall, 1 was obtained in 47% yield from 3. The structures and synthetic mechanisms of by-products (five compounds) of 2 were also clarified.

2-Phenyl- and 2-benzyl-N-[(trichloromethyl)thio]succinimides, and fungicidal compositions thereof

N-[(Trichloromethyl)thio]succinimides of the formula STR1 WHERE R1, R2 and R3 independently are hydrogen or alkyl having from 1 to 6 carbon atoms, and n is zero or the integer 1, having antifungal activity, a method of use thereof as antifungal agents, and antifungal compositions comprising them are disclosed.