433920-87-7

Usage

Structure

Aromatic aldehyde with a pyrazole ring attached to a benzene ring and a methoxy group at the para position

Uses

Synthesis of pharmaceuticals, agrochemicals, and organic compounds; research and development for drug discovery and material science applications

Properties

Valuable building block for creating new and diverse chemical entities

Upstream product

• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 1269834-34-5 C₁₁H₁₂N₂O₂ 
• 288-13-1 NH-pyrazole 
• 41608-64-4 methyl 3-methoxy-4-aminobenzoate 
• 35387-92-9 methyl 4-iodo-3-methoxybenzoate 
• 1269834-30-1 C₁₂H₁₂N₂O₃ 

Relevant academic research and scientific papers

BROAD SPECTRUM ANTIVIRAL COMPOSITIONS AND METHODS

Novel thiazole- and isoquinoline- containing compounds are presented that are useful for treating and/or preventing broad-spectrum viral infections. Methods of treating and/or preventing broad-specturm viral infections are also presented. These compounds have shown inhibitio of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.

Synthesis and preliminary evaluation of curcumin analogues as cytotoxic agents

A series of curcumin analogues with different substituents at the 4-position of the phenyl group were synthesized and screened for in vitro cytotoxicity against a panel of human cancer cell lines. Several novel curcumin analogues, especially 32 and 34, exhibited selective and potent cytotoxic activity against human epidermoid carcinoma cell line A-431 and human glioblastoma cell line U-251, implying their specific potential in the chemoprevention and chemotherapy of skin cancer and glioma. The preliminary SAR information extracted from the results suggested that introduction of appropriate substituents to the 4′-positions could be a promising approach for the development of new cytotoxic curcumin analogues with special selectivity for A-431 and U-251 cell lines.

6-O-acyl ketolide antibacterials

6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

6-O-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

6-0-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.