433922-57-7

Usage

Uses

Used in Organic Chemistry Synthesis:
1-(5-Bromopyridin-2-yl)-1H-pyrazole is used as a building block for the synthesis of complex organic compounds in various fields, including pharmaceuticals, agrochemicals, and functional materials. Its unique structure with a pyrazole moiety and a halogenated pyridine part makes it a valuable intermediate in the development of new molecules with potential applications in these industries.
Used in Pharmaceutical Industry:
1-(5-Bromopyridin-2-yl)-1H-pyrazole is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic effects. 1-(5-Bromopyridin-2-yl)-1H-pyrazole's reactivity and functional groups can be utilized to create novel molecules with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
Used in Agrochemical Industry:
1-(5-Bromopyridin-2-yl)-1H-pyrazole is used as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and reactivity can be exploited to develop new active ingredients with improved efficacy, selectivity, and environmental compatibility. This can lead to the creation of safer and more effective agrochemicals for crop protection and management.
Used in Functional Materials:
1-(5-Bromopyridin-2-yl)-1H-pyrazole is used as a component in the development of functional materials with specific properties, such as conductivity, magnetism, or luminescence. Its unique structure and reactivity can be utilized to create new materials with tailored properties for various applications, including sensors, catalysts, and electronic devices.

InChI:InChI=1/C8H6BrN3/c9-7-2-3-8(10-6-7)12-5-1-4-11-12/h1-6H

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 288-13-1 NH-pyrazole 
• 380380-69-8 5-bromo-2-(1H-1,2,3-triazol-1-yl)pyridine 
• 383142-29-8 5-bromo-2-(1H-pyrrol-1-yl)pyridine 
• 1043906-08-6 1-(5-bromopyridin-2-yl)-1H-benzo[d]imidazole 
• 380381-18-0 5-bromo-2-(1H-imidazol-1-yl)pyridine 
• 766-11-0 5-bromo-2-fluoropyridine 

Downstream Products

• 1218791-02-6 2-(1H-pyrazol-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 1416000-02-6 2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one 
• 1351523-97-1 4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine 

Relevant academic research and scientific papers

Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines

A novel series of amide functionalized imidazo[1,2-a]pyridine (14a–14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14j showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC50 values of 0.021 ± 0.0012 μM, 0.95 ± 0.039 μM, 0.091 ± 0.0053 μM, and 0.24 ± 0.032 μM, respectively.

Copper-Catalyzed C-N Bond Exchange of N-Heterocyclic Substituents around Pyridine and Pyrimidine Cores

A copper-catalyzed transfer N-heteroarylation strategy using a C-N bond exchange reaction is described. This reaction accommodates a wide range of pyridine and pyrimidine rings bearing halogen atoms, which have wide utility for subsequent transformations. This method provides a direct and operationally simple approach for modifying complex molecules by the exchange of N-heterocyclic substituents.

Pyridonaphthyridine PI3K/MTOR Dual Inhibitors and Preparation and Use Thereof

The present invention relates to a pyridonaphthyridine compound as represented by general formula (I), which has a dual PI3K and mTOR inhibition effect, and its pharmaceutically acceptable salt, stereoisomer and deuteride thereof, wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the specification; the present invention also relates to a method for preparing said compound, a pharmaceutical composition and a pharmaceutical formulation containing said compound, and uses of said compound in treating and/or preventing a proliferative disease and in the manufacture of a medicament for treating and/or preventing a proliferative disease.

PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF

The present invention relates to a pyridonaphthyridine compound as represented by general formula (I), which has a dual PI3K and mTOR inhibition effect, and its pharmaceutically acceptable salt, stereoisomer and deuteride thereof, wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the specification; the present invention also relates to a method for preparing said compound, a pharmaceutical composition and a pharmaceutical formulation containing said compound, and uses of said compound in treating and/or preventing a proliferative disease and in the manufacture of a medicament for treating and/or preventing a proliferative disease.

6-O-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

6-O-acyl ketolide antibacterials

6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

6-0-carbamoyl ketolide antibacterials

6-O-Carbamoyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, R5, R6, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.