433941-98-1Relevant academic research and scientific papers
Synthesis and antimicrobial evaluation of new series of quinazolin-5-one derivatives
Haggam, Reda A.,Soylem, Essam. A.,Assy, Mohamed. G.,Arastiedy, Marium. F.
, p. 1715 - 1723 (2020)
A new series of quinazolinone derivatives were synthesized starting with anthranilic acid and cinnamoylisothiocyanate in high yields 55–99%. Their structures were elucidated by 1H/13C NMR, FTIR spectroscopy, MS and elemental analysis. The study of the biological activity of all the novel compounds is reported. The minimal inhibitory concentration of some quinazolin-5-one derivatives showed potential activity against both Gram (+ve) and Gram (?ve) microorganisms more than the reference cefotaxime. In addition, some derivatives of quinazolin-5-one can be considered as antifungal agents comparing with the standard drug nystatin.
