4341-57-5 Usage
Organic compound
Contains an indole ring
Substitution
Iodo group and carbonyl group
Potential applications
Pharmaceutical field
Building block
Synthesis of various bioactive molecules
Functional groups
Hydrazine and carbothioamide
Versatility
Potential for further chemical manipulations and derivatization
Importance in medicinal chemistry research
Can serve as a starting point for the development of new drugs and bioactive compounds
Check Digit Verification of cas no
The CAS Registry Mumber 4341-57-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,4 and 1 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4341-57:
(6*4)+(5*3)+(4*4)+(3*1)+(2*5)+(1*7)=75
75 % 10 = 5
So 4341-57-5 is a valid CAS Registry Number.
4341-57-5Relevant articles and documents
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain
Chiyanzu, Idan,Hansell, Elizabeth,Gut, Jiri,Rosenthal, Philip J.,McKerrow, James H.,Chibale, Kelly
, p. 3527 - 3530 (2007/10/03)
While commercial isatins were practically inactive against the target proteases, thiosemicarbazone derivatives were found to be active. The most active compound from the series displayed an inhibitory IC50 value of 1 μM against rhodesain. One thiosemicarbazone was found to be active against all three proteases with inhibitory IC50 values of 10 μM or less. A combination of N-benzylation and appropriate substitution on the aromatic portion of the isatin scaffold was generally found to be beneficial especially against cruzain for ketone inhibitors.
