434319-49-0Relevant articles and documents
Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5
Peukert, Stefan,Brendel, Joachim,Pirard, Bernard,Brüggemann, Andrea,Below, Peter,Kleemann, Heinz-Werner,Hemmerle, Horst,Schmidt, Wolfgang
, p. 486 - 498 (2007/10/03)
The voltage-gated potassium channel Kv1.5 is regarded as a promising target for the development of new atrial selective drugs with fewer side effects. In the present study the discovery of ortho, ortho-disubstituted bisaryl compounds as blockers of the Kv