4347-18-6 Usage
Uses
Used in Pharmaceutical Industry:
4-oxo-L-proline is utilized as a precursor in the synthesis of pharmaceutical compounds, particularly for the production of the neurotransmitter GABA, which is vital for the central nervous system's function.
Used in Biochemical Research:
In the field of biochemical research, 4-oxo-L-proline is employed as a key intermediate to study the metabolic pathways of proline and its involvement in the proline cycle and collagen synthesis, contributing to a better understanding of these processes.
Used in Neurodegenerative Disorder Treatment:
4-oxo-L-proline is explored as a potential therapeutic agent for neurodegenerative disorders due to its role in GABA synthesis, which may help in managing the symptoms and progression of such conditions.
Used in Cancer Therapy:
4-oxo-L-proline is investigated for its potential role in cancer treatment, as its metabolic pathways may offer avenues for developing targeted therapies against cancer cells.
Used in Collagen Production:
In the cosmetic and healthcare industries, 4-oxo-L-proline may be used to support collagen production, which is essential for maintaining skin elasticity and overall connective tissue health.
Check Digit Verification of cas no
The CAS Registry Mumber 4347-18-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,4 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4347-18:
(6*4)+(5*3)+(4*4)+(3*7)+(2*1)+(1*8)=86
86 % 10 = 6
So 4347-18-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h4,6H,1-2H2,(H,8,9)/t4-/m0/s1
4347-18-6Relevant academic research and scientific papers
Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles
Smart, Tristan J.,Hamed, Refaat B.,Claridge, Timothy D.W.,Schofield, Christopher J.
supporting information, (2019/11/26)
Studies on the substrate selectivity of recombinant ferrous-iron- and 2-oxoglutarate-dependent proline hydroxylases (PHs) reveal that they can catalyse the production of dihydroxylated 5-, 6-, and 7-membered ring products, and can accept bicyclic substrates. Ring-substituted substrate analogues (such hydroxylated and fluorinated prolines) are accepted in some cases. The results highlight the considerable, as yet largely untapped, potential for amino acid hydroxylases and other 2OG oxygenases in biocatalysis.
