434958-85-7

Usage

Uses

Used in Organic Synthesis:
1-Boc-5-hydroxyindole is used as an intermediate for the preparation of various indole derivatives, providing a versatile starting material for the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
1-Boc-5-hydroxyindole is used as a key building block in the development of pharmaceutical compounds, owing to its potential biological activity and the presence of the Boc protecting group, which allows for selective functionalization and manipulation of the indole ring.
Used in Pharmaceutical Industry:
1-Boc-5-hydroxyindole is used as a precursor for the synthesis of pharmaceutical products, leveraging its potential biological activity and the versatility provided by the Boc protecting group for the creation of diverse chemical compounds with therapeutic applications.
Used in Agrochemical Industry:
1-Boc-5-hydroxyindole is used as a precursor for the synthesis of agrochemical products, taking advantage of its potential biological activity and the selective functionalization capabilities offered by the Boc protecting group to develop compounds with applications in agriculture and pest control.

InChI:InChI=1/C13H15NO3/c1-13(2,3)17-12(16)14-7-6-9-8-10(15)4-5-11(9)14/h4-8,15H,1-3H3

Upstream product

• 1953-54-4 indol-5-ol 
• 49761-82-2 tert-butyl 1H-imidazole-1-carboxylate 
• 182344-70-3 5-bromo-indole-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 170147-29-2 tert-butyl 5-(benzyloxy)-1H-indole-1-carboxylate 

Downstream Products

• 890316-66-2 tert-butyl 5-(3-(benzamido)-4-(tert-butoxycarbonyl)phenoxy)-1H-indole-1-carboxylate 
• 943772-81-4 5-[4-(4-bromo-phenylcarbamoyl)-2-nitro-phenoxy]-indole-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

1, 5-disubstituted indole derivative with leukotreines A4 hydrolase inhibiting effect and application

The invention relates to a 1, 5-disubstituted indole derivative with leukotreines A4 hydrolase inhibiting effect. The 1, 5-disubstituted indole derivative has the function of inhibiting leukotreines A4 hydrolase. The 1, 5-disubstituted indole derivative i

Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate

The conversion of aryl halides to phenols under mild reaction conditions is a longstanding and formidable challenge in organic chemistry. Herein, we report the rational design of a broadly applicable Pd-catalyzed method to prepare phenols with benzaldehyde oxime as a hydroxide surrogate. These reactions occur under mildly basic conditions and enable the late-stage hydroxylation of several functionally-dense drug-like aryl halides.

Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction

Parallel synthesis and mass-directed purification of a modular ligand library, high-throughput experimentation, and rational ligand evolution have led to a novel copper catalyst for the synthesis of phenols with a traceless hydroxide surrogate. The mild reaction conditions reported here enable the late-stage synthesis of numerous complex, druglike phenols.

TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS

The invention relates to a compound of formula I: (I) or a pharmaceutically acceptable salt thereof and/or stereoisomers thereof. The compounds of the invention are useful in therapy.

Ligand compound of alpha7 nicotinic acetylcholine receptor and application of ligand compound

The embodiment of the invention provides a ligand compound of an alpha7 nicotinic acetylcholine receptor, the ligand compound has one of the following general formulas: wherein (1) X and R1 are shown in the description, and R7 is halogen; (2) R2 is hydrogen, and R3 is halogen or amino; or R3 is hydrogen, and R2 is halogen or amino; (3) R6 is hydrogen, and R4 and R5 are synthesized into a compound shown in the description; or R4 is hydrogen, and R5 and R6 are synthesized into a compound shown in the description; R8 is halogen; and (4) Y is nitrogen or carbon, Z is shown in the description, and R9 and R10 are respectively halogens. The provided ligand compound is an excellent ligand compound of the alpha7 nicotinic acetylcholine receptor. After being chemically marked radioactively, the provided ligand compound of the alpha7 nicotinic acetylcholine receptor can serve as a PET photographic developer.

Chemoselective N-acylation of indoles and oxazolidinones with carbonylazoles

Unique reactivity: In the presence of more reactive amine and alcohol functional groups and of carboxylic acids, the chemoselective N-acylation of indoles (see scheme) and oxazolidinones is achieved by taking advantage of the unique reactivity of carbonylazole acylating agents with catalytic amounts of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Copyright

Nucleoside Aryl Phosphoramidates for the Treatment of RNA-Dependent RNA Viral Infection

The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are

JAK INHIBITOR

A JAK inhibitor comprising, as an active ingredient, a nitrogen-containing heterocyclic compound represented by formula (I) {wherein W represents a nitrogen atom or -CH-; X represents -C (=O) - or -CHR4- (wherein R4 represents a hydrogen atom, or the like); R1 represents the formula described below [wherein Q1 represents-CR8-(wherein R8 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); Q2 represents -NR15- (wherein R15 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like); and R5 and R6 may be the same or different and each represents a hydrogen atom, halogen, carboxy, substituted or unsubstituted lower alkyl, or the like], or the like; and R2 and R3 may be the same or different and each represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like} or a pharmaceutically acceptable salt thereof.

ANTI-VIRAL COMPOUNDS

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

INDOLYL-THIENO`3,4-B!PYRAZIN-3-ONE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS

This invention relates to a compound of Formula (I): (I) and its use in treating hyper-proliferative disorders and diseases associated with angiogenesis.