4350-38-3

Upstream product

• 502483-46-7 (3,4-dichlorophenyl)(pyridin-2-yl)methanol 
• 18282-59-2 4-bromo-1,2-dichlorobenzene 
• 109-04-6 2-bromo-pyridine 
• 18880-04-1 3,4-dichlorobenzyl bromide 

Downstream Products

• 32060-43-8 [3-(3,4-dichloro-phenyl)-3-[2]pyridyl-propyl]-dimethyl-amine 

Relevant academic research and scientific papers

Direct Triflylation of Benzylic C—H Bonds with Pyridine as a Directing Group

The first example of benzylic C—H triflylation was accomplished with pyridine as a directing group. The reaction of various 2-benzylpyridines and (CF3SO2)2O in the presence of NEt3 in CH2Cl2 proceeded smoothly to afford the corresponding benzyl triflones in moderate to high yields.

Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C?H Borylation of Benzyl-2-Pyridines at Room Temperature

A convenient and ligand-free iridium-catalyzed dehydrogenative ortho C?H borylation of benzyl-2-pyridines has been developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)]2. The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities. (Figure presented.).