435281-29-1Relevant academic research and scientific papers
Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part I
Zhang, Guobao,Ren, Pingda,Gray, Nathanael S.,Sim, Taebo,Liu, Yi,Wang, Xia,Che, Jianwei,Tian, Shin-Shay,Sandberg, Mark L.,Spalding, Tracy A.,Romeo, Russell,Iskandar, Maya,Chow, Donald,Martin Seidel,Karanewsky, Donald S.,He, Yun
scheme or table, p. 5618 - 5621 (2009/05/30)
A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src kinase family. Highly efficient parallel syntheses were devised to prepare analogues for SAR studies. A number of these 4-amino-6-benzimidazole-pyrimidines exhibited single-digit nanomolar IC50s against Lck in biochemical and cellular assays. These 4-amino-6-benzimidazole-pyrimidines represent a new class of tyrosine kinase inhibitors.
Substituted benzimidazoles, processes for their preparation, their use as medicaments, and medicaments comprising them
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, (2008/06/13)
The invention relates to the use of compounds of formula I for the production of a medicament for the treatment of illnesses which can be influenced by inhibition of the Na+/H+ exchanger, and to a medicament comprising them. in which R1 to R9 have the meanings shown in the claims.
