919084-46-1Relevant academic research and scientific papers
Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part I
Zhang, Guobao,Ren, Pingda,Gray, Nathanael S.,Sim, Taebo,Liu, Yi,Wang, Xia,Che, Jianwei,Tian, Shin-Shay,Sandberg, Mark L.,Spalding, Tracy A.,Romeo, Russell,Iskandar, Maya,Chow, Donald,Martin Seidel,Karanewsky, Donald S.,He, Yun
, p. 5618 - 5621 (2008)
A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src kinase family. Highly efficient parallel syntheses were devised to prepare analogues for SAR studies. A number of these 4-amino-6-benzimidazole-pyrimidines exhibited single-digit nanomolar IC50s against Lck in biochemical and cellular assays. These 4-amino-6-benzimidazole-pyrimidines represent a new class of tyrosine kinase inhibitors.
