4354-75-0

Upstream product

• 78216-00-9 acetyl-epipicropodophyllotoxin 
• 4375-06-8 epipicropodophyllotoxin 
• 4375-07-9 epipodophyllotoxin 
• 79289-93-3 (4aR,5R,6S,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthrene-5-carboxylic acid 
• 74879-22-4 6-bromobenzo-1,3-dioxole-5-carboxaldehyde dimethyl acetal 
• 21852-50-6 3,4,5-trimethoxybenzyl bromide 
• 86301-74-8 5-Dimethoxymethyl-6-(3,4,5-trimethoxy-benzyl)-benzo[1,3]dioxole 
• 79305-58-1 (4aR,5R,6S,11bS)-2,2-Dimethyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-cyclopenta[b]phenanthrene-5-carboxylic acid methyl ester 
• 1256-91-3 (5S,6R,7R,8S)-8-Hydroxy-7-hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 
• 518-28-5 podofilox 
• 86301-75-9 dimethyl 4-(3,4-trans)-hydroxy-6,7-(methylenedioxy)-1-(1,2-cis)-(3',4',5'-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-2,3-cis-dicarboxylate 
• 75101-88-1 C₂₃H₂₄O₉ 
• 79289-93-3 epipodophyllic acid 4,11-acetonide 
• 99463-57-7 (4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid 

Downstream Products

• 4375-06-8 epipicropodophyllotoxin 
• 477-47-4 (+/-)-epiisopodophyllotoxin 
• 59123-24-9 (±)-β-apopicropodophyllin 
• 477-47-4 picropodophyllotoxin 
• 477-47-4 (+/-)-isopodophyllotoxin 
• 477-47-4 (+/-)-epipodophyllotoxin 

Relevant academic research and scientific papers

Comprehensive Synthetic Route to Eight Diastereomeric Podophyllum Lignans

An oxabicyclo compound, 9, prepared in 47percent yield through an isobenzofuran intermediate was converted with excellent regio- and stereocontrol to eight (+/-)-lignan lactones of the podophyllotoxin series.One of the eight, epiisopicropodophyllin, 36, t

TOTAL SYNTHESIS OF (+/-)-PODOPHYLLOTOXIN AND (+/-)-EPIPODOPHYLLOTOXIN

A novel approach to (+/-)-epipodophyllotoxin (2c) and hence also to (+/-)-podophyllotoxin (1c) is described, involving as a key-step the stereoselective ring closure of the TMS-ester derived from 17a to the tetralin derivative 30c with mesyl chloride.

TOTAL SYNTHESIS OF (+/-)-PODOPHYLLOTOXIN AND (+/-)-EPIPODOPHYLLOTOXIN.

A novel approach to (+/-)-epipodophyllotoxin (2) and hence also (+/-)-podophyllotoxin (1) is described, involving as a key-step the stereoselective ring closure of the TMS-ester derived from 14a to the tetralin derivative 15 with mesyl chloride.