436-14-6

Upstream product

• 74-88-4 methyl iodide 
• 110548-95-3 evoxine 
• 55740-46-0 4,8-dimethoxy-furo[2,3-b]quinolin-7-yl tri-O-acetyl-α-L-6-deoxy-mannopyranoside 
• 83-95-4 skimmianine 
• 85769-56-8 3-formylmethyl-1-methyl-4,7,8-trimethoxy-2-quinolone 
• 123613-76-3 4,7,8,9a-Tetramethoxy-9-methyl-9,9a-dihydro-furo[2,3-b]quinoline; hydriodide 
• 55740-45-9 glycoperine 
• 106006-02-4 4-ethoxy-7,8-dimethoxy-furo[2,3-b]quinoline 

Relevant academic research and scientific papers

QUINOLINE AND INDOLOPYRIDOQUINAZOLINE ALKALOIDS FROM VEPRIS LOUISII

The structures of two new 2-quinolone alkaloids from the stem bark of Vepris louisii, N-methylpreskimmianine and veprisine (7,8-dimethoxy-N-methylflindersine) have been deduced from their spectral data and confirmed by partial synthesis from known compounds.Two minor indolopyridoquinazoline alkaloids were also isolated and identified as the already known 1-hydroxyrutaecarpine and the hitherto unknown 7,8-dehydro derivative of 1-hydroxyrutaecarpine. - Key Word Index: Vepris louisii; Rutaceae; stem bark; alkaloids; 2-quinolones; veprisine; N-methylpreskimmianine; indolopyridoquinazoline; 1-hydroxyrutaecarpine; 7,8-dehydro-1-hydroxyrutaecarpine.

Quinoline alkaloids. Part 26. Pseudobases from the reaction of furoquinolinones with methyl iodide. A new route to 3-(3-methyl-2-oxobutyl)- quinolin-2(1H)-ones

Reaction of 2-isopropyl-9-methylfuro[2,3-b]quinolin-4(9H)-ones (5) with methyl iodide gave salts believed to be pseudobase hydriodides (7), which were converted with base into 4-methoxy-1-methyl-3-(3-methyl-2-oxobutyl)quinolin- 2(1H)-ones (6); the analogous pseudobase derivative (12) from the furoquinoline alkaloid skimmianine gives the furoquinolin-4-one isoskimmianine on further reaction with methyl iodide. The mechanisms of these reactions and of the acid-catalysed rearrangement of furoquinolinones (5) are discussed.